切换至 "中华医学电子期刊资源库"

中华肝脏外科手术学电子杂志 ›› 2019, Vol. 08 ›› Issue (05) : 465 -468. doi: 10.3877/cma.j.issn.2095-3232.2019.05.020

所属专题: 文献

综述

外泌体在肝细胞癌中的作用
杨嘉睿1, 邓美海1,(), 梁豪1, 熊志勇1, 姚志成1   
  1. 1. 510630 广州,中山大学附属第三医院肝胆外科
  • 收稿日期:2019-06-18 出版日期:2019-10-10
  • 通信作者: 邓美海
  • 基金资助:
    广东省自然科学基金(2016A030313848); 广州市科技计划项目(201704020175)

Role of exosome in hepatocellular carcinoma

Jiarui Yang1, Meihai Deng1(), Hao Liang1   

  • Received:2019-06-18 Published:2019-10-10
  • Corresponding author: Meihai Deng
引用本文:

杨嘉睿, 邓美海, 梁豪, 熊志勇, 姚志成. 外泌体在肝细胞癌中的作用[J]. 中华肝脏外科手术学电子杂志, 2019, 08(05): 465-468.

Jiarui Yang, Meihai Deng, Hao Liang. Role of exosome in hepatocellular carcinoma[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2019, 08(05): 465-468.

[1]
Kubo S. Prevention of cancer recurrence after treatment for hepatitis C virus-related hepatocellular carcinoma by interferon therapy[J]. Clin J Gastroenterol, 2009, 2(2): 65-70.
[2]
Zhao Y, Li Y, Ma H, et al. Modification of sialylation mediates the invasive properties and chemosensitivity of human hepatocellular carcinoma[J]. Mol Cell Proteomics, 2014,13(2): 520-536.
[3]
Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses[J]. Nat Rev Immunol, 2009, 9(8): 581-593.
[4]
Forner A, Bruix J. Biomarkers for early diagnosis of hepatocellular carcinoma[J]. Lancet Oncol, 2012, 13(8): 750-751.
[5]
Dyson J, Jaques B, Chattopadyhay D, et al. Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team[J].J Hepatol, 2014, 60(1): 110-117.
[6]
Johnstone RM, Adam M, Hammond JR, et al. Vesicle formation during reticulocyte maturation. association of plasma membrane activities with released vesicles (exosomes)[J]. J Biol Chem, 1987, 262(19): 9412-9420.
[7]
Théry C. Exosomes: secreted vesicles and intercellular communications[J]. F1000 Biol Rep, 2011(3): 15.
[8]
Zhang C, Yang X, Qi Q, et al. lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma[J]. Cancer Biomark, 2018, 21(3): 651-659.
[9]
Zhao X, Wu Y, Duan J, et al. Quantitative proteomic analysis of exosome protein content changes induced by hepatitis B virus in Huh-7 cells using SILAC labeling and LC-MS/MS[J]. J Proteome Res, 2014, 13(12): 5391-5402.
[10]
Zhang J, Lu S, Zhou Y, et al. Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes[J]. Proteomics, 2017, 17(13/14): 1700103.
[11]
He M, Qin H, Poon TC, et al. Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs[J]. Carcinogenesis, 2015, 36(9): 1008-1018.
[12]
Zhu L, Qu XH, Sun YL, et al. Novel method for extracting exosomes of hepatocellular carcinoma cells[J]. World J Gastroenterol, 2014, 20(21): 6651-6657.
[13]
Wang H, Hou L, Li A, et al. Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma[J]. Biomed Res Int, 2014: 864894.
[14]
Sugimachi K, Matsumura T, Hirata H, et al. Identification ofa bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation[J]. Br J Cancer, 2015, 112(3): 532-538.
[15]
Sohn W, Kim J, Kang SH, et al. Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma[J]. Exp Mol Med, 2015(47): e184.
[16]
Fornari F, Ferracin M, Trerè D, et al. Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, identify cirrhotic patients with HCC[J]. PLoS One, 2015, 10(10): e0141448.
[17]
Chiba M, Kimura M, Asari S. Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines[J]. Oncol Rep, 2012, 28(5): 1551-1558.
[18]
Xue X, Wang X, Zhao Y, et al. Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A[J]. Biochem Biophys Res Commun, 2018, 502(4): 515-521.
[19]
Zhang Z, Li X, Sun W, et al. Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis[J]. Cancer Lett, 2017, 397: 33-42.
[20]
Fujiki T, Miura T, Maura M, et al. TAK1 represses transcription of the human telomerase reverse transcriptase gene[J]. Oncogene, 2007, 26(36): 5258-5266.
[21]
Kogure T, Lin WL, Yan IK, et al. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth[J]. Hepatology, 2011, 54(4): 1237-1248.
[22]
Fang T, Lv H, Lv G, et al. Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer[J]. Nat Commun, 2018, 9(1): 191.
[23]
Conigliaro A, Costa V, Lo Dico A, et al. CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA[J]. Mol Cancer, 2015(14): 155.
[24]
Ikeda Y, Imai Y, Kumagai H, et al. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo[J]. Proc Natl Acad Sci U S A, 2004, 101(29): 10732-10737.
[25]
Ramakrishnaiah V, Thumann C, Fofana I, et al. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells[J]. Proc Natl Acad Sci U S A, 2013, 110(32): 13109-13113.
[26]
Yang Y, Han Q, Hou Z, et al. Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction[J]. Cell Mol Immunol, 2017, 14(5): 465-475.
[27]
Xiao W, Dong W, Zhang C, et al. Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells[J]. Eur J Med Res, 2013(18): 61.
[28]
Xiao WH, Sanren GW, Zhu JH, et al. Effect of 5-aza-2'-deoxycytidine on immune-associated proteins in exosomes from hepatoma[J]. World J Gastroenterol, 2010, 16(19): 2371-2377.
[29]
Lv LH, Wan YL, Lin Y, et al. Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro[J]. J Biol Chem, 2012, 287(19): 15874-15885.
[30]
Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol, 2007, 9(6): 654-659.
[31]
Wang F, Li L, Piontek K, et al. Exosome miR-335 as a novel therapeutic strategy in hepatocellular carcinoma[J]. Hepatology, 2018, 67(3): 940-954.
[32]
Pan Q, Ramakrishnaiah V, Henry S, et al. Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)[J]. Gut, 2012, 61(9): 1330-1339.
[33]
Wei JX, Lv LH, Wan YL, et al. Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells[J]. Hepatology, 2015, 61(4): 1284-1294.
[34]
Qi H, Liu C, Long L, et al. Blood exosomes endowed with magnetic and targeting properties for cancer therapy[J]. ACS Nano, 2016, 10(3): 3323-3333.
[35]
Qu Z, Wu J, Wu J, et al. Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro[J]. J Exp Clin Cancer Res, 2016, 35(1): 159.
[36]
Lou G, Song X, Yang F, et al. Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma[J]. J Hematol Oncol, 2015(8): 122.
[37]
Takahashi K, Yan IK, Wood J, et al. Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy[J]. Mol Cancer Res, 2014, 12(10): 1377-1387.
[38]
马博,任军,姜晗昉,等.肿瘤源性外切体负载的间充质干细胞抗肿瘤活性的实验研究[J].北京大学学报(医学版),2008, 40(5): 494-499.
[39]
Lu Z, Zuo B, Jing R, et al. Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models[J]. J Hepatol, 2017, 67(4): 739-748.
[1] 魏小勇. 原发性肝癌转化治疗焦点问题探讨[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 602-607.
[2] 张其坤, 商福超, 李琪, 栗光明, 王孟龙. 联合脾切除对肝癌合并门静脉高压症患者根治性切除术后的生存获益分析[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 613-618.
[3] 严庆, 刘颖, 邓斐文, 陈焕伟. 微血管侵犯对肝癌肝移植患者生存预后的影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 624-629.
[4] 张文华, 陶焠, 胡添松. 不同部位外生型肝癌临床病理特点及其对术后肝内复发和预后影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 651-655.
[5] 韩宇, 张武, 李安琪, 陈文颖, 谢斯栋. MRI肝脏影像报告和数据系统对非肝硬化乙肝患者肝细胞癌的诊断价值[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 669-673.
[6] 张维志, 刘连新. 基于生物信息学分析IPO7在肝癌中的表达及意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 694-701.
[7] 陈安, 冯娟, 杨振宇, 杜锡林, 柏强善, 阴继凯, 臧莉, 鲁建国. 基于生物信息学分析CCN4在肝细胞癌中表达及其临床意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 702-707.
[8] 叶文涛, 吴忠均, 廖锐. 癌旁组织ALOX15表达与肝癌根治性切除术后预后的关系[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 708-712.
[9] 吴晨瑞, 廖锐, 贺强, 潘龙, 黄平, 曹洪祥, 赵益, 王永琛, 黄俊杰, 孙睿锐. MDT模式下肝动脉灌注化疗联合免疫靶向治疗肝细胞癌多处转移一例[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 713-716.
[10] 杜锡林, 谭凯, 贺小军, 白亮亮, 赵瑶瑶. 肝细胞癌转化治疗方式[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 597-601.
[11] 何传超, 肖治宇. 晚期肝癌综合治疗模式与策略[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 486-489.
[12] 王孟龙. 肿瘤生物学特征在肝癌肝移植治疗中的意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 490-494.
[13] 王楚风, 蒋安. 原发性肝癌的分子诊断[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 499-503.
[14] 王峰杰, 王礼光, 廖珊, 刘颖, 符荣党, 陈焕伟. 腹腔镜右半肝切除术治疗肝癌的安全性与疗效[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 517-522.
[15] 张海涛, 贾哲, 马超, 张其坤, 武聚山, 郭庆良, 曾道炳, 栗光明, 王孟龙. 手术切除与射频消融治疗血管周围型单发小肝癌临床疗效分析[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 523-527.
阅读次数
全文


摘要