通过文献计量学可视化分析探讨全球范围内微血管侵犯（MVI）预测肝细胞癌（HCC）预后的热点与趋势。

文献检索2014年1月至2024年3月Web of Science数据库中MVI预测肝癌预后的相关文章，文献类型包括article和review，语种：English。采用CiteSpace软件从发表文献的年份、作者、机构、国家、期刊及关键词等方面进行统计和可视化分析。

2014年至2024年HCC-MVI研究领域的发文量共计1 778篇，总体呈逐年上升趋势，被引频次6 843。共49个国家参与发文，发文量最高的5个国家分别是中国1 156篇、美国176篇、韩国157篇、日本119篇、意大利85篇。该领域的发文量主要集中在欧洲、亚洲、南美洲。中国发文量最多，最活跃的国家和机构分别是中国和中国海军军医大学。最活跃和被引用最多的作者分别是Lau WY和Bruix J。中国机构的国际合作较少，而美国中心度最高且与其他国家的合作更加紧密。共同引用网络中关键节点的聚类和时间线视图显示，从2014年开始研究热点持续时间最长是血管形成，而近两年最新出现的频次最高的相关关键词是预测模型。关键词的突显图显示，2021年以前主要围绕生物标志物、肝移植和手术切除的选择展开。2014年开始肝切除术后的复发和预后是研究的重点。2015年开始出现关于HCC的生物标志物及长期生存率，还有预测因子相关研究一直持续爆发。最近，该领域的兴趣开始转向关于HCC的影像组学学习及其相关列线图计算。影像组学及列线图计算是近3年突显的关键词，是目前HCC-MVI领域的重要研究方向。

基于CiteSpace可视化分析显示，近10年来MVI预测肝癌切除术后的预后相关研究不断发展，血管问题一直受到关注，随着影像组学的发展，影像方面的模型构建备受关注。

To investigate the hot spots and trends of microvascular invasion (MVI) in predicting clinical prognosis of hepatocellular carcinoma (HCC) worldwide through bibliometric and visual analysis.

Studies related to MVI in predicting clinical prognosis of HCC were obtained from Web of Science core literature database from January 2014 to March 2024. Study types included article and review in English. Statistical and visual analyses of the published articles were performed from the aspects of year, author, institution, country, journal and keywords by using CiteSpace software.

From 2014 to 2024, 1 778 articles were published in the field of HCC-MVI research, showing an overall increasing trend year by year, with a citation frequency of 6 843. These articles were published from 49 countries. The five countries with the highest number of articles were China (1 156), the United States (176), South Korea (157), Japan (119) and Italy (85), mainly from Europe, Asia and North America. The most active country was China and the most active institution was Naval Medical University from China. The most active and cited authors were Lau WY and Bruix J. Chinese institutions conducted less international cooperation, while other countries carried out closer cooperation. The United States had the highest degree of centralization and closer cooperation with other countries. The clustering and timeline map of key nodes in the co-cited network showed that angiogenesis has been the hotspot with the longest duration of research since 2014. Prediction model was the latest keyword with the highest frequency in recent two years. The highlight map of keywords revealed that before 2021, studies mainly focused on biomarkers, liver transplantation and the selection of surgical resection. The recurrence and prognosis after hepatectomy were the hot spots after 2014. In 2015, HCC-related biomarkers and long-term survival rate became the hot spots. The number of predictor-related studies has been significantly increased. Recently, the interests in this field began to shift to radiomics study of HCC and related nomogram calculation. Radiomics and nomogram calculation were the prominent keywords in recent three years, which are currently the important research directions in HCC-MVI field.

CiteSpace-based visualization analysis shows that the research on MVI in predicting clinical prognosis of HCC after surgical resection has been ever advanced in recent decade. Vascular disease has drawn widespread attention. With the advancement of radiomics, the construction of radiomic models captivates extensive attention.