探讨具有臻圆^TM技术的Emprint^TM微波消融系统在肝细胞癌（肝癌）治疗中的安全性及疗效。

回顾性分析2019年1月至2019年5月在中山大学附属第三医院诊治的24例肝癌患者临床资料。其中男18例，女6例；平均年龄（52±11）岁。患者均签署知情同意书，符合医学伦理学规定。采用Emprint^TM微波消融系统行微波消融治疗，消融功率100 W。根据第一针消融时间不同分为5 min组和10 min组，术中即时超声造影（CEUS）评估第一针消融范围，观察术后1个月完全消融率及消融相关主要并发症发生率。两组第一针消融范围比较采用t检验。

24例患者共27个病灶在实时超声引导下Emprint^TM微波消融系统消融，其中5 min组11个病灶和10 min组16个病灶。病灶消融次数中位数2（1～7）次，消融总时间为10（5～45） min。5 min组消融灶长径为（29.3±2.6） mm，明显小于10 min组的（33.7±6.7）mm（t=-2.389，P<0.05）；而两组横径、圆度指数和消融灶面积相应为（25.8±3.0）mm、0.88±0.10、（2 384±406）mm²和（27.0±6.3）mm、0.81±0.14、（2 939±1 091）mm²，差异无统计学意义（t=-0.657，1.518，-1.857；P>0.05）。术后1个月复查增强CT或MRI显示，除2例未返院进行复查，余25个病灶均完全消融，完全消融率为100%；复查患者均未发现消融相关主要并发症。

Emprint^TM微波消融系统用于肝癌治疗安全、有效。在100 W功率下，5 min消融时间可能较10 min更能获得接近于规则、可预测的球形消融范围。

To evaluate the safety and clinical efficacy of Emprint^TM microwave ablation system with Thermosphere^TM technology in the treatment of hepatocellular carcinoma (HCC).

Clinical data of 24 HCC patients admitted to the Third Affiliated Hospital of Sun Yat-sen University from January 2019 to May 2019 were retrospectively analyzed. Among them, 18 patients were male and 6 female, aged (52±11) years on average. The informed consents of all patients were obtained and the local ethical committee approval was received. The microwave ablation was performed with Emprint^TM microwave ablation system with an ablation power of 100 W. According to different ablation time of the first insertion, all lesions were divided into the 5-min and 10-min groups. The ablation range of first insertion was assessed by intraoperative contrast-enhanced ultrasound (CEUS). Complete ablation rate and the incidence of major complications induced by ablation were observed at postoperative 1 month. The ablation range of first insertion was compared between two groups by t test.

27 lesions from 24 patients were ablated with real-time ultrasound-guided Emprint^TM microwave ablation system, including 11 lesions in the 5-min group and 16 lesions in the 10-min group. The median ablation frequency was 2(1-7) times, and the total ablation time was 10(5-45) min. In the 5-min group, the maximal diameter of ablated lesions was (29.3±2.6) mm, significantly shorter than (33.7±6.7) mm in the 10-min group (t=-2.389, P<0.05). The transverse diameter, round index and ablation area in the 5-min group were (25.8±3.0) mm, 0.88±0.10, (2 384±406) mm2, which did not significantly differ from (27.0±6.3) mm, 0.81±0.14 and (2 939±1 091) mm² in the 10-min group (t=-0.657, 1.518, -1.857; P>0.05). Enhanced CT scan or MRI at postoperative 1 month showed that 25 lesions were completely ablated with a complete ablation rate of 100% except 2 cases who did not receive reexamination. Reexamination revealed no major complications related to ablation.

Emprint^TM microwave ablation system is a safe and effective method for HCC. 5-min ablation with a power of 100 W can obtain more regular and predictable spherical ablation range compared with 10-min ablation.