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中华肝脏外科手术学电子杂志 ›› 2026, Vol. 15 ›› Issue (04) : 515 -522. doi: 10.3877/cma.j.issn.2095-3232.2026.04.003

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血液病脾切除治疗中的热点问题与发展方向
苏德强, 田晓丰, 李梓康, 杨佳, 丁绪鹏, 曹宏()   
  1. 130033 长春,吉林大学中日联谊医院普通外科
  • 收稿日期:2025-09-02 出版日期:2026-08-10
  • 通信作者: 曹宏
  • 基金资助:
    吉林省科技发展计划项目(YDZI202401462ZYTS)

Hot topics and development direction in splenectomy for hematological diseases

Deqiang Su, Xiaofeng Tian, Zikang Li, Jia Yang, Xupeng Ding, Hong Cao()   

  1. Department of General Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
  • Received:2025-09-02 Published:2026-08-10
  • Corresponding author: Hong Cao
引用本文:

苏德强, 田晓丰, 李梓康, 杨佳, 丁绪鹏, 曹宏. 血液病脾切除治疗中的热点问题与发展方向[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(04): 515-522.

Deqiang Su, Xiaofeng Tian, Zikang Li, Jia Yang, Xupeng Ding, Hong Cao. Hot topics and development direction in splenectomy for hematological diseases[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2026, 15(04): 515-522.

脾脏是人体重要的造血和免疫器官。脾脏在血液病中的作用复杂,它不仅是血细胞的破坏场所,也参与免疫反应、血液细胞生成及过滤等多种生理功能。在血液系统疾病中,脾脏的病理性增大或功能亢进可导致血液细胞异常破坏,从而加重贫血、血小板减少等症状。脾切除术作为一种有效的治疗手段,能够减轻脾脏对血液成分的负面影响,然而随着对脾脏功能及其在免疫调节中角色的深入理解,以及随着新药物疗法的应用,部分血液病患者通过非手术治疗也可以获得良好的临床效果,因此脾切除在血液系统疾病治疗中的角色也发生了变化。脾切除的适应证、时机以及术后管理等问题仍然存在一定的争议和挑战。本文回顾血液病脾切除术临床应用、疗效及相关研究最新进展,旨在探讨当前在脾切除治疗中的热点问题与未来发展方向。

Spleen is a vital hematopoietic and immune organ in human body. Spleen plays a complex role in hematological diseases. It is not only the site where blood cells are destroyed, but also participates in multiple physiological functions such as immune response, hematopoiesis and filtration, etc. In hematological diseases, pathological enlargement of the spleen or hypersplenism can lead to abnormal destruction of blood cells, thereby aggravating anemia, thrombocytopenia and other symptoms. Splenectomy, as an effective treatment, can mitigate the negative effect of spleen on blood components. However, with in-depth understanding of spleen function and its role in immune regulation, as well as the application of new drug therapy, partial patients with hematological diseases can also obtain favorable clinical outcomes through non-surgical treatment. Hence, the role of splenectomy in the treatment of hematological diseases has also changed. Disputes and challenges still exist in the indications, timing and postoperative management of splenectomy. In this article, clinical application, efficacy and the latest research progress in splenectomy for hematological diseases were reviewed, aiming to discuss current hot topics and future direction of splenectomy.

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