Investigation on sexual function of recipients after liver transplantation and impact factors analysis

doi:10.3877/cma.j.issn.2095-3232.2014.05.005

Abstract

Abstract:

Objective

To investigate the sexual function and its impact factors in recipients after liver transplantation (LT).

Methods

Clinical data of 69 recipients undergoing LT in Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University from June 2007 to July 2012 were analyzed retrospectively. The informed consents of all recipients were obtained and the ethical committee approval was received. All the recipients were male with age ranging from 30 to 55 years old and a median of 43 years old. The sexual function was normal in all patients before being diseased. The recipients were surveyed using self-designed questionnaire on sexual life quality of liver transplant recipients and direct inquiry. The recipients were divided into sexual dysfunction group (n=23) and intact sexual function group (n=46). The correlation between sexual dysfunction and clinical indexes of the recipients was analyzed. The ratio of two groups was compared by Chi-square test.

Results

The incidence of sexual dysfunction of liver transplant recipients after operation was 33% (23/69), which was significantly lower than that before operation [88% (61/69) ] (χ²=7.56, P<0.05). The incidence of sexual dysfunction after operation in recipients with chronic severe hepatitis and decompensated liver cirrhosis [49% (17/35)] was significantly higher than those with compensated liver cirrhosis and liver inflammatory granuloma [18% (6/34)] (χ²=4.52, P<0.05). The incidence of sexual dysfunction was significantly higher in recipients who considered that sexual life causing adverse impacts on the liver graft [83% (20/24)], compared with those who considered that sexual life causing no impacts on the liver graft [7% (3/45) (χ²=11.63, P<0.05)].

Conclusions

The sexual function of the recipients after LT improved significantly, compared with that before LT. The incidence of sexual function is closely related with the primary diseases and the cognition on sexual life of the recipients.

Key words: Liver transplantation, Sexual fuction, Cognition, Postoperative care

Xiaomeng Yi, Yuling An, Haijin Lyu, Xuxia Wei, Liang Xiong, Jianrong Liu, Huimin Yi, Guihua Chen. Investigation on sexual function of recipients after liver transplantation and impact factors analysis[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2014, 03(05): 279-282.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhgzwkssxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3232.2014.05.005

https://zhgzwkssxdzzz.cma-cmc.com.cn/EN/Y2014/V03/I05/279

Figures/Tables 1

References 18

[1]	Burra P, Germani G, Masier A, et al. Sexual dysfunction in chronic liver disease: is liver transplantation an effective cure?[J]. Transplantation, 2010, 89(12):1425-1429.
[2]	Baranyi A, Rosler D, Rothenhausler HB. The effects of depressive symptoms on quality of life, sexual satisfaction and cognitive performance after orthotopic liver transplantation[J]. Neuropsychiatr, 2012, 26(2):59-64.
[3]	Klein J, Tran SN, Mentha-Dugerdil A, et al. Assessment of sexual function and conjugal satisfaction prior to and after liver transplantation[J]. Ann Transplant, 2013(18):136-145.
[4]	Coelho JC, Matias JE, Zeni Neto C, et al. Sexual function in males undergoing liver transplantation[J]. Rev Assoc Med Bras, 2003, 49(4):413-417.
[5]	Tome S, Wells JT, Said A, et al. Quality of life after liver transplantation: a systematic review[J]. J Hepatol, 2008, 48(4):567-577.
[6]	Haavisto A, Korkman M, Tormanen J, et al. Visuospatial impairment in children and adolescents after liver transplantation[J]. Pediatr Transplant, 2011, 15(2):184-192.
[7]	Burra P, Germani G, Masier A, et al. Sexual dysfunction in chronic liver disease: is liver transplantation an effective cure?[J]. Transplantation, 2010, 89(12):1425-1429.
[8]	Watt KD, Pedersen RA, Kremers WK, et al. Evolution of causes and risk factors for mortality post-liver transplant: results of the NIDDK long-term follow-up study[J]. Am J Transplant, 2010, 10(6):1420-1427.
[9]	Lim KB, Schiano TD. Long-term outcome after liver transplantation[J]. Mt Sinai J Med, 2012, 79(2):169-189.
[10]	Corruble E, Barry C, Varescon I, et al. Depressive symptoms predict long-term mortality after liver transplantation[J]. J Psychosom Res, 2011, 71(1):32-37.
[11]	Dimartini A, Dew MA, Chaiffetz D, et al. Early trajectories of depressive symptoms after liver transplantation for alcoholic liver disease predicts long-term survival[J]. Am J Transplant, 2011, 11(6):1287-1295.
[12]	Jin SG, Yan LN, Xiang B, et al. Posttraumatic stress disorder after liver transplantation[J]. Hepatobiliary Pancreat Dis Int, 2012, 11(1):28-33.
[13]	Guimaro MS, Lacerda SS, Aguilar MR, et al. Post-traumatic stress disorders, mood disorders, and quality of life in transplant recipients with acute liver failure[J]. Transplant Proc, 2011, 43(1):187-188.
[14]	Zaydfudim V, Feurer ID, Landman MP, et al. Reduction in corticosteroids is associated with better health-related quality of life after liver transplantation[J]. J Am Coll Surg, 2012, 214(2):164-173.
[15]	Volk ML, Hagan M. Organ quality and quality of life after liver transplantation[J]. Liver Transpl, 2011, 17(12):1443-1447.
[16]	Alonso EM, Limbers CA, Neighbors K, et al. Cross-sectional analysis of health-related quality of life in pediatric liver transplant recipients[J]. J Pediatr, 2010, 156(2):270-276.
[17]	Huda A, Newcomer R, Harrington C, et al. High rate of unemployment after liver transplantation: analysis of the United Network for Organ Sharing database[J]. Liver Transpl, 2012, 18(1):89-99.
[18]	Huyghe E, Kamar N, Wagner F, et al. Erectile dysfunction in liver transplant patients[J]. Am J Transplant, 2008, 8(12):2580-2589.

组别	例数	年龄（岁）		原发病		MELD评分（分）		术后并发症		对性生活的认知
组别	例数	<45	≥45	慢性重型肝炎及肝硬化（失代偿期）	肝硬化（代偿期）及肝脏炎性肉芽肿	<30	≥30	无	有	认为对移植肝无影响	认为对移植肝有影响
性功能障碍组	23	12	11	17	6	19	4	12	11	3	20
性功能正常组	46	21	25	18	28	39	7	27	19	42	4
χ²值	?	1.89		4.52		2.43		2.56		11.63
P值	?	>0.05		<0.05		>0.05		>0.05		<0.05

组别	例数	年龄（岁）		原发病		MELD评分（分）		术后并发症		对性生活的认知
组别	例数	<45	≥45	慢性重型肝炎及肝硬化（失代偿期）	肝硬化（代偿期）及肝脏炎性肉芽肿	<30	≥30	无	有	认为对移植肝无影响	认为对移植肝有影响
性功能障碍组	23	12	11	17	6	19	4	12	11	3	20
性功能正常组	46	21	25	18	28	39	7	27	19	42	4
χ²值	?	1.89		4.52		2.43		2.56		11.63
P值	?	>0.05		<0.05		>0.05		>0.05		<0.05

Please choose a citation manager

Content to export