Protective effect of propofol anesthesia on liver ischemia-reperfusion injury after hepatectomy: a Meta-analysis

doi:10.3877/cma.j.issn.2095-3232.2021.01.013

Abstract

Abstract:

Objective

To systematically evaluate the effect of propofol anesthesia on liver ischemia-reperfusion injury (IRI) after hepatectomy with hepatic portal occlusion.

Methods

Literature review was performed in databases of PubMed, EMBASE, Web of Science, Cochane Library, CNKI, Wanfang Data, VIP and SinoMed from inception to December 2019. The randomized controlled studies evaluating the effect of propofol anesthesia on liver IRI after hepatectomy were retrieved. The outcome indexes included superoxide dismutase (SOD), malondialdehyde (MDA), ALT and AST. Meta-analysis was performed using RevMan 5.3 software.

Results

A total of 23 articles, 1 317 patients were eventually included. 746 cases received propofol anesthesia (study group) and 571 cases were given with non-propofol anesthesia (control group). Meta-analysis showed that after blood re-opening for 15 min and 30-45 min, the SOD level in the study group was significantly higher than that in the control group (MD=15.08, 24.20; P<0.05), whereas the MDA level was significantly lower than that in the control group (MD=-5.73, -5.28; P<0.05). After re-opening for 15 min, the ALT and AST levels in the study group were significantly lower than those in the control group (MD=-24.46, -23.85; P<0.05). At postoperative 1 d, the ALT level in the study group was significantly lower than that in the control group (MD=-32.75, P<0.05). At postoperative 3-4 d, the AST level in the study group was also remarkably lower than that in the control group (MD=-10.03, P<0.05).

Conclusions

Propofol anesthesia probably exerts a protective effect upon liver IRI after hepatectomy.

Key words: Propofol, Reperfusion injury, Hepatectomy, Meta-analysis

Ainiwaer Aikebaierjiang·, Ning Ma, Tuxun Tuerhongjiang·, Apaer Shadike·, Anweier Nuerzatijiang·, Jing Wu, Qi Zeng, Haiping Ma. Protective effect of propofol anesthesia on liver ischemia-reperfusion injury after hepatectomy: a Meta-analysis[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2021, 10(01): 59-63.

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