Effect of donor management scheme on organ donation outcome

doi:10.3877/cma.j.issn.2095-3232.2021.06.012

Abstract

Abstract:

Objective

To evaluate the effect of Organ Donation Work Group (ODWG) management scheme on the outcome of organ donation.

Methods

Clinical data of 182 donors admitted to Organ Procurement Organization (OPO) in the Third Affiliated Hospital of Sun Yat-sen University from January 2018 to June 2020 were retrospectively analyzed. Among them, 150 donors were male and 32 female, aged (42±15) years on average. Regarding March 2019 as the time point, all donors were divided into the ODWG (n=108) and control groups (n=74). The informed consents of all patients were obtained and the local ethical committee approval was received. The donor donation types and parameters of quality control of donated organs were statistically compared between two groups. The rate comparison was performed byChi-square test.

Results

The success rate of organ donation was 70%(128/182). Among them, 91 cases were donation after brain death (DBD) and 80 cases were donation after cardiac death (DCD). In the ODWG group, the proportion of DBD cases was 67%(68/102), significantly higher than 33%(23/69) in the control group (χ²=18.37, P<0.05). In the ODWG group, the emergency organ procurement rate was 1%(1/102), significantly lower than 10%(7/69) in the control group (χ²=5.71, P<0.05). In the ODWG group, the number of procured organs was 295, the number of discarded organs was 22, the utilization rate of organs was 93%(273/295), the output rate of organs was 268%(273/102). They were correspondingly 198, 26, 87%(172/198) and 249%(172/69) in the control group. The organ utilization rate and output rate in the ODWG group were higher than those in the control group.

Conclusions

ODWG management scheme can significantly improve the organ donation rate and expand the organ pool, which is a protocol to guarantee the efficacy and safety of organ donation-transplantation.

Key words: Organ donation, Organ transplantation, Donor management, Intensive care

Jianrong Liu, Tianwei Xiong, Mi Zhou, Xvxia Wei, Yuling An, Xiaomeng Yi, Lijuan Li, Pinglan Lu, Mingming Fan, Ziyu Li, Yang Yang, Huimin Yi. Effect of donor management scheme on organ donation outcome[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2021, 10(06): 589-593.

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References 21

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组别	例数	年龄（岁，±s）	性别（例）		血型（例）
组别	例数	年龄（岁，±s）	男	女	A	B	O	AB
ODWG组	108	43±15	84	24	30	19	53	6
对照组	74	41±16	66	8	13	21	29	6
统计值		t=0.80	χ²=3.95		χ²=5.47
P值		0.422	0.047		0.140
组别	例数	Na（mmol/L，±s)	Scr[μmol/L，M（Q_R）]	ALB(g/L，±s)	ALT[U/L，M（Q_R）]	TB[μmol/L，M（Q_R）]	DB[μmol/L，M（Q_R）]
ODWG组	108	156±16	119(140)	35±6	33(50)	13(22)	5(5)
对照组	74	154±13	131(194)	34±7	39(80)	14(16)	6(9)
统计值		t=0.48	Z=-0.89	t=1.69	Z=-0.76	Z=-0.18	Z=-1.83
P值		0.634	0.371	0.094	0.447	0.861	0.067

组别	例数	年龄（岁，±s）	性别（例）		血型（例）
组别	例数	年龄（岁，±s）	男	女	A	B	O	AB
ODWG组	108	43±15	84	24	30	19	53	6
对照组	74	41±16	66	8	13	21	29	6
统计值		t=0.80	χ²=3.95		χ²=5.47
P值		0.422	0.047		0.140
组别	例数	Na（mmol/L，±s)	Scr[μmol/L，M（Q_R）]	ALB(g/L，±s)	ALT[U/L，M（Q_R）]	TB[μmol/L，M（Q_R）]	DB[μmol/L，M（Q_R）]
ODWG组	108	156±16	119(140)	35±6	33(50)	13(22)	5(5)
对照组	74	154±13	131(194)	34±7	39(80)	14(16)	6(9)
统计值		t=0.48	Z=-0.89	t=1.69	Z=-0.76	Z=-0.18	Z=-1.83
P值		0.634	0.371	0.094	0.447	0.861	0.067

组别	例数	维护时间（h，±s）	捐献前死亡（例）	器官紧急获取（例）	每位供者捐献器官数量（个）	顺利捐献（例）	DBD/DCD（例）
ODWG组	108	40±19	6	1	2.7±1.0	77	68/34
对照组	74	47±35	5	7	2.5±0.9	51	23/46
统计值		t=-1.66	χ²=0.11	χ²=5.71	t=1.30	χ²=0.05	χ²=18.37
P值		0.099	0.760	0.008	0.196	0.816	<0.001

组别	例数	维护时间（h，±s）	捐献前死亡（例）	器官紧急获取（例）	每位供者捐献器官数量（个）	顺利捐献（例）	DBD/DCD（例）
ODWG组	108	40±19	6	1	2.7±1.0	77	68/34
对照组	74	47±35	5	7	2.5±0.9	51	23/46
统计值		t=-1.66	χ²=0.11	χ²=5.71	t=1.30	χ²=0.05	χ²=18.37
P值		0.099	0.760	0.008	0.196	0.816	<0.001

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