To evalute the safety and efficacy of laparoscopic sleeve gastrectomy (LSG) combined with laparoscopic cholecystectomy (LC) in the treatment of obese patients complicated with cholecystolithiasis.

Clinical data of 32 patients with obesity complicated with cholecystolithiasis who underwent LSG combined with LC in the Affiliated Hospital of Yunnan University from January 2020 to January 2022 were retrospectively analyzed. The informed consents of all patients were obtained and the local ethical committee approval was received. Among them, 8 patients were male and 24 female, aged from 20 to 55 years, with a median age of 34 years. Operative complications and clinical efficacy at postoperative 6 months were observed. Preoperative and postoperative BMI, lipid level, glucose level and blood pressure were compared by t test.

LSG combined with LC was successfully performed in all patients. No evident complications, such as postoperative bleeding, gastric fistula, bile leakage, biliary tract injury and gastric cavity stenosis, were recorded during perioperative period. Preoperative body weight was (97±13) kg, which was decreased to (70±9) kg at postoperative 6 months. Preoperative BMI was (35.6±6.4) kg/m², which was declined to (23.2±1.3) kg/m² after surgery. In 28 patients with hyperlipidemia, preoperative lipid level was (12.8±7.5) mmol/L and decreased to (2.2±1.1) mmol/L after surgery. In 12 patients with type 2 diabetes mellitus, preoperative fasting glucose level was (12.5±1.7) mmol/L and decreased to (5.5±0.9) mmol/L postoperatively. In 10 patients with hypertension, preoperative blood pressure level was (168±13)/(104±9) mmHg and declined to (138±11)/(90±6) mmHg after surgery (1 mmHg=0.133 kPa)(t=8.641, 8.505, 31.272, 10.443, 8.862, 8.414; P<0.05).

It is safe and feasible to perform LSG combined with LC for obese patients complicated with cholecystolithiasis, which can remarkably mitigate metabolic diseases, such as obesity, hyperlipidemia, hypertension and hyperglycemia, etc. LSG combined with LC yields equivalent efficacy to that of LSG or LC alone, whereas it has advantages in alleviating trauma and lowering surgical cost, etc.