Research progress of ferroptosis in liver ischemia-reperfusion injury

doi:10.3877/cma.j.issn.2095-3232.2024.01.022

Abstract

Abstract:

Ferroptosis is a newly-discovered form of cell death in recent years. It is believed that the body can dynamically regulate ferroptosis mainly through ferroptosis defense system (System Xc-pathway and MVA signaling pathway) and ferroptosis executive system (PUFA-PL metabolism, peroxidation and iron metabolism). More and more studies have indicated that ferroptosis is correlated with ischemia-reperfusion injury of different organs. Among them, macrophage extracellular traps, Maresin-1, bone marrow mesenchymal stem cells modified by heme oxygenase 1 and HUWE-1 may all affect liver ischemia-reperfusion injury by affecting ferroptosis. Therefore, in this article, related studies between ferroptosis and liver ischemia-reperfusion injury were reviewed, aiming to provide theoretical basis and practical guidance for liver organ protection.

Key words: Liver, Ischemia-reperfusion injury (IRI), Ferroptosis, Lipid hydroperoxide, Reactive oxygen species (ROS)

Le Li, Zhijun Zhu. Research progress of ferroptosis in liver ischemia-reperfusion injury[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(01): 109-113.

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References 35

[1]	Guo Z, Luo T, Mo R, et al. Ischemia-free organ transplantation-a review[J]. Curr Opin Organ Transplant, 2022, 27(4):300-304.
[2]	Liu H, Man K. Man new insights in mechanisms and therapeutics for short- and long-term impacts of hepatic ischemia reperfusion injury post liver transplantation[J]. Int J Mol Sci, 2021, 22(15):8210.
[3]	Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5):1060-1072.
[4]	Yamane D, Hayashi Y, Matsumoto M, et al. FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication[J]. Cell Chem Biol, 2022, 29(5):799-810, e4.
[5]	Li J, Tao HS, Wang WQ, et al. The detection and verification of two heterogeneous subgroups and a risk model based on ferroptosis-related genes in hepatocellular carcinoma[J]. J Oncol, 2022:1182383.
[6]	Ong SY, Gurrin LC, Dolling L, et al. Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial[J]. Lancet Haematol, 2017, 4(12):e607-614.
[7]	Wang S, Liu Z, Geng J, et al. An overview of ferroptosis in non-alcoholic fatty liver disease[J]. Biomed Pharmacother, 2022(153):113374.
[8]	Wu J, Meng QH. Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease[J]. World J Gastroenterol, 2020, 26(31):4567-4578.
[9]	Yamada N, Karasawa T, Kimura H, et al. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure[J]. Cell Death Dis, 2020, 11(2):144.
[10]	Lillo-Moya J, Rojas-Sole C, Munoz-salamanca D, et al. Targeting ferroptosis against ischemia/reperfusion cardiac injury[J]. Antioxidants, 2021, 10(5):667.
[11]	Martin-Sanchez D, Fontecha-barriuso M, Martinez-Moreno JM, et al. Ferroptosis and kidney disease[J]. Nefrologia, 2020, 40(4):384-394.
[12]	Xu S, He Y, Lin L, et al. The emerging role of ferroptosis in intestinal disease[J]. Cell Death Dis, 2021, 12(4):289.
[13]	Yamada N, Karasawa T, Wakiya T, et al. Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis[J]. Am J Transplant, 2020, 20(6):1606-1618.
[14]	Li YC, Cao YM, Xiao J, et al. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury[J]. Cell Death Differ, 2020, 27(9):2635-2650.
[15]	Wang P, Cui Y, Ren Q, et al. Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis[J]. Cell Death Dis, 2021, 12(5):447.
[16]	Stockwell BR, Jiang X, Gu W. Emerging mechanisms and disease relevance of ferroptosis[J]. Trends Cell Biol, 2020, 30(6):478-490.
[17]	Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy[J]. Protein Cell, 2021, 12(8):599-620.
[18]	Liu M, Kong XY, Yao Y, et al. The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review[J]. Ann Transl Med, 2022, 10(6):368.
[19]	Bersuker K, Hendricks JM, Li ZP, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis[J]. Nature, 2019, 575(7784):688-692.
[20]	Dixon SJ, Winter GE, Musavi LS, et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death[J]. ACS Chem Biol, 2015, 10(7):1604-1609.
[21]	Magtanong L, Ko PJ, To M, et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state[J]. Cell Chem Biol, 2019, 26(3):420-432, e9.
[22]	Feng H, Schorpp K, Jin J, et al. Transferrin receptor is a specific ferroptosis marker[J]. Cell Rep, 2020, 30(10):3411-3423, e7.
[23]	Mumbauer S, Pascual J, Kolotuev L, et al. Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis[J]. PLoS Genet, 2019, 15(9):e1008396.
[24]	Patel SJ, Frey AG, Palenchar DJ, et al. A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly[J]. Nat Chem Biol, 2019, 15(9):872-881.
[25]	Wu S, Yang J, Sun GL, et al. Macrophage extracellular traps aggravate iron overload-related liver ischaemia/reperfusion injury[J]. Br J Pharmacol, 2021, 178(18):3783-3796.
[26]	Friedmann Angeli JP, Scheider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J]. Nat Cell Biol, 2014, 16(12):1180-1191.
[27]	Ye J, Peng J, Liu KZ, et al. MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury[J]. Am J Physiol Gastrointest Liver Physiol, 2022, 323(3):G283-293.
[28]	Li X, Wu LL, Tian X, et al. miR-29a-3p in exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells alleviates steatotic liver ischemia-reperfusion injury in rats by suppressing ferroptosis via iron responsive element binding protein 2[J]. Oxid Med Cell Longev, 2022:6520789.
[29]	Wu Y, Jiao HK, Yue YB, et al. Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury[J]. Cell Death Differ, 2022, 29(9):1705-1718.
[30]	Weng W, Hu Z, Pan YF. Macrophage extracellular traps: current opinions and the state of research regarding various diseases[J].J Immunol Res, 2022:7050807.
[31]	Han J, Li H, Bhandari SW, et al. Maresin conjugates in tissue regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury[J]. J Cell Mol Med, 2020, 24(8):4736-4747.
[32]	Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis[J]. Redox Biol, 2019(23):101107.
[33]	Lou G, Chen Z, Zheng M, et al. Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases[J]. Exp Mol Med, 2017, 49(6):e346.
[34]	Pegtel DM, Gould SJ. Exosomes[J]. Annu Rev Biochem, 2019(88):487-514.
[35]	Qi L, Xu XQ, Qi XP. The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases[J]. Front Cell Infect Microbiol, 2022(12):905906.

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