Research progress and application of quercetin in regulating hepatic ischemia-reperfusion injury

doi:10.3877/cma.j.issn.2095-3232.2024.02.022

Abstract

Abstract:

Hepatic ischemia-reperfusion injury (HIRI) is an inevitable event during liver resection or liver transplantation because it requires a certain period of time for hepatic inflow occlusion. HIRI severely affects surgical prognosis, especially for patients with fatty liver disease and cirrhosis. Quercetin is a natural flavonoid compound, which exerts anti-inflammatory, anti-oxidation, anti-aging and anti-cancer effects. Recent studies have shown that quercetin plays an important role in the mechanism underlying the protection of multi-organ dysfunction such as heart, brain, kidney, liver and so on. In addition, the anti-HIRI role of quercetin in liver protection has gradually become the hot topic of current research. According to literature review, quercetin has been proven to play an effective role in anti-oxidative stress, mitigating inflammatory reaction, anti-apoptosis and autophagy, which has potential to alleviate HIRI in clinical practice.

Key words: Quercetin, Liver, Ischemia-reperfusion injury, Anti-oxidative stress, Anti-inflammatory

Jie Pei, Benliang Mao, Dingying Hao, Wei Yuan, Yong Yan, Fan Wu, Pengzhen Wang, Bailin Wang. Research progress and application of quercetin in regulating hepatic ischemia-reperfusion injury[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(02): 244-249.

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