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Chinese Journal of Hepatic Surgery(Electronic Edition) ›› 2024, Vol. 13 ›› Issue (06): 763-768. doi: 10.3877/cma.j.issn.2095-3232.2024999

• Expert Opinions • Previous Articles    

Progress in immunotargeted therapy for gallbladder cancer

Weijie Chen1, Xiaodong He1,()   

  1. 1.Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China
  • Received:2024-06-08 Online:2024-12-10 Published:2024-11-22
  • Contact: Xiaodong He

Abstract:

Gallbladder cancer is a rare tumor with high invasiveness and malignant metastatic potential. Traditional treatments,such as surgical resection,chemotherapy and radiotherapy,have certain limitations in improving the survival rate of patients. As a novel therapeutic strategy,immunotargeted therapy has attracted widespread attention in recent years. In this article,recent research progress in immunotargeted therapy for gallbladder cancer was reviewed. Immunotherapy can inhibit tumor growth and metastasis by activating the patients' immune system. Targeted therapy has shown certain efficacy in the treatment of gallbladder cancer via several targets. However,challenges still exist in immunotargeted therapy,such as immune tolerance,immune escape and immune-related adverse events,etc. Therefore,subsequent researches and clinical trials should be carried out to improve the therapeutic effect and survival rate of patients with gallbladder cancer.

Key words: Gallbladder cancer, Immune therapy, Targeted therapy, Conversion therapy, Programmed death-1 (PD-1), Immune checkpoint inhibitors (ICI), Chimeric antigen receptor T-cell immunotherapy (CAR-T)

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