Research progress in gut microbes in the incidence and development of pancreatitis

doi:10.3877/cma.j.issn.2095-3232.2025.03.023

Abstract

Abstract:

Acute pancreatitis （AP） is one of the common acute abdomen in the digestive system. It varies in disease severity， constantly complicated with pancreatic or peripancreatic infection. Especially if AP progresses into acute necrotizing pancreatitis， it will significantly increase the risk of multiple organ failure and even death. In addition， the incidence rate of AP is on the rise. Tremendous progress has been made in the study of the changes and treatment of gut microbes in AP patients. However， complicated relationship exists between the diversity and complexity of gut microbes and its role in target organs. AP patients not only develop impaired intestinal barrier function and altered microbial diversity， but also experience increased intestinal bacterial translocation induced by local or systemic inflammatory stimuli， forming a vicious circle and further elevating the proportion of critically ill patients. Therefore， restoring intestinal mucosal barrier function and diversifying gut microbes may be the key to prevent disease progression. In this article， the changes of intestinal mucosal barrier damage and intestinal microbiota imbalance during AP were reviewed by retrieving relevant literature， aiming to provide theoretical basis for the treatment of AP.

Key words: Acute pancreatitis, Intestinal barrier function, Gut microbiotas, Research advances

Yong Lan, Jing Liu, Zhiqi Yang, Lang Wu, Xiaochun Sha, Minghao Li. Research progress in gut microbes in the incidence and development of pancreatitis[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 14(03): 481-486.

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