Laparoscopic liver resection for posterosuperior tumors is a challenging procedure in laparoscopic liver resection. How to guarantee the safety of this procedure has been one of the keys issues for liver surgeons. In this article, the development history of laparoscopic liver resection was reviewed, and the naming of resection of tumors in the posterosuperior segment of liver (including S7, S8 and S4a) was discussed, and the importance of unified naming was emphasized. The challenges of liver resection for posterosuperior tumors were analyzed, including the difficulty of exposure due to deep location of S7 and S8 segments as well as bleeding control. Three main surgical approaches including lateral, thoracoscopic and abdominal approaches were illustrated, and their advantages and disadvantages were analyzed. Based on literature review combined with clinical practice, the key steps of this procedure were illustrated, including patient's posture, Trocar site, liver dissociation, dissociation of the third porta hepatis and liver partition, and the possibility of technical breakthrough in the future was predicted, including robot-assisted surgery and novel procedure using Laennec's capsule.