Research progress in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

doi:10.3877/cma.j.issn.2095-3232.2026.01.020

Abstract

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is a type of digestive tract carcinoma with extremely high degree of malignancy and poor prognosis. At present, relevant research mainly focuses on the core driver gene mutation (such as KRAS/TP53), dense fibrotic microenvironment characterized by abnormal activation and immunosuppression of cancer-associated fibroblasts (CAFs), and the mechanism of chemotherapy resistance. The frontier exploration directions cover targeted therapy (such as KRAS inhibitors), immune microenvironment regulation, metabolic pathway intervention and screening of early diagnostic biomarkers. In this article, biological characteristics of CAFs were illustrated, including cell origin, functional phenotype classification and molecular heterogeneity. The key role of CAFs in the progression of PDAC was unraveled from the perspectives of regulating malignant biological behavior, constructing dynamic microenvironment network and mediating angiogenesis and immunosuppression, etc. Based on the development of spatial transcriptome and multiplex immunofluorescence imaging, analysis of epigenetic regulation mechanism and optimization of combined treatment regimens, this study was designed to provide novel ideas for precise treatment and improve clinical prognosis of PDAC patients.

Key words: Pancreatic ductal adenocarcinoma, Cancer-associated fibroblasts, Tumor microenvironment, Signaling pathways, Immune modulation

Tiexin Liu, Zhenxia Wang. Research progress in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2026, 15(01): 124-131.

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