Meta-analysis on correlation between hepatitis C virus infection and risk of cholangiocarcinoma

doi:10.3877/cma.j.issn.2095-3232.2015.02.005

Abstract

Abstract:

Objective

To explore the correlation between hepatitis C virus infection and the risk of cholangiocarcinoma (CCA) through Meta-analysis.

Methods

Literatures that were formally published prior to August, 2013 were searched on National Knowledge Infrastructure (CNKI), PubMed, EMBASE and MEDLINE databases using English, Chinese terms mainly including hepatitis C virus, HCV, cholangiocarcinoma, bile duct cancer, intrahepatic, extrahepatic. Moreover, associated literatures were also searched by manual searching. Data from the literatures were merged and the correlation between hepatitis C virus and risk of CCA, intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC) was analyzed respectively. Heterogeneity test was conducted using Q test. RR value of each study and pooled data were calculated and forest graph was drawn to display the results and features of each study. Funnel plot and Egger test were used to identify the publication bias.

Results

A total of 16 case-control studies and 2 cohort studies (total 873 501 patients) were included in the final analysis. Meta-analysis showed that hepatitis C virus infection was not associated with the occurrence of CCA (RR=2.36, P>0.05) and hepatitis C virus infection was the risk factor for the occurrence of ICC and ECC (RR=4.10, 1.48; P<0.05).Funnel plot and Egger test showed no evidence for publication bias.

Conclusion

Hepatitis C virus infection is associated with the risks of ICC and ECC, especially ICC.

Key words: Hepacivirus, Bile duct neoplasms, Intrahepatic cholangiocarcinoma, Meta-analysis

Hao Li, Zhengjun Zhang, Zunqiang Zhou, Guangwen Zhou. Meta-analysis on correlation between hepatitis C virus infection and risk of cholangiocarcinoma[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2015, 04(02): 79-83.

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References 24

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分组		文献数	异质性检验
分组		文献数	Q值	P值	I² (%)
研究设计		?	?	?	?
?	病例对照	13	65.10	<0.05	78.60
?	队列研究	2	0.00	>0.05	0.00
病例来源		?	?	?	?
?	以医院为基础	10	31.80	<0.05	71.70
?	以人群为基础	3	2.79	>0.05	28.30
地区分布		?	?	?	?
?	北美	4	2.81	<0.05	0.00
?	亚洲	8	28.30	>0.05	75.30
?	欧洲	1	0.00	?	0.00

分组		文献数	异质性检验
分组		文献数	Q值	P值	I² (%)
研究设计		?	?	?	?
?	病例对照	13	65.10	<0.05	78.60
?	队列研究	2	0.00	>0.05	0.00
病例来源		?	?	?	?
?	以医院为基础	10	31.80	<0.05	71.70
?	以人群为基础	3	2.79	>0.05	28.30
地区分布		?	?	?	?
?	北美	4	2.81	<0.05	0.00
?	亚洲	8	28.30	>0.05	75.30
?	欧洲	1	0.00	?	0.00

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