[1] |
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424.
|
[2] |
Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132.
|
[3] |
Dong LQ, Peng LH, Ma LJ, et al. Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma[J]. J Hepatol, 2020, 72(5):896-908.
|
[4] |
Huang A, Zhao X, Yang XR, et al. Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma[J]. J Hepatol, 2017, 67(2):293-301.
|
[5] |
Torrecilla S, Sia D, Harrington AN, et al. Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma[J]. J Hepatol, 2017, 67(6):1222-1231.
|
[6] |
Feo F, Pascale RM. Multifocal hepatocellular carcinoma: intrahepatic metastasis or multicentric carcinogenesis?[J]. Ann Transl Med, 2015, 3(1):4.
|
[7] |
Chen YJ, Yeh SH, Chen JT, et al. Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma[J]. Gastroenterology, 2000, 119(2):431-440.
|
[8] |
Ochiai T, Urata Y, Yamano T, et al. Clonal expansion in evolution of chronic hepatitis to hepatocellular carcinoma as seen at an X-chromosome locus[J]. Hepatology, 2000, 31(3):615-621.
|
[9] |
Huang ZY, Liang BY, Xiong M, et al. Long-term outcomes of repeat hepatic resection in patients with recurrent hepatocellular carcinoma and analysis of recurrent types and their prognosis: a single-center experience in China[J]. Ann Surg Oncol, 2012, 19(8):2515-2525.
|
[10] |
Kim JM, Kwon CH, Joh JW, et al. Intrahepatic metastasis is more risky than multiple occurrence in hepatocellular carcinoma patients after curative liver resection[J]. Hepatogastroenterology, 2015, 62(138):399-404.
|
[11] |
Poon RT, Fan ST, Ng IO, et al. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma[J]. Cancer, 2000, 89(3):500-507.
|
[12] |
Kubo S, Nishiguchi S, Hirohashi K, et al. Clinicopathological criteria for multicentricity of hepatocellular carcinoma and risk factors for such carcinogenesis[J]. Jpn J Cancer Res, 1998, 89(4):419-426.
|
[13] |
Matsumoto Y, Fujii H, Matsuda M, et al. Multicentric occurrence of hepatocellular carcinoma: diagnosis and clinical significance[J]. J Hepatobiliary Pancreat Surg, 2001, 8(5):435-440.
|
[14] |
Tajima T, Yoshimitsu K, Irie H, et al. Detecting postsurgical recurrent hepatocellular carcinoma with multiphasic helical computed tomography: intrahepatic metastasis or multicentric occurrence?[J]. J Comput Assist Tomogr, 2005, 29(1):42-50.
|
[15] |
Lequoy M, Desbois-Mouthon C, Wendum D, et al. Somatostatin receptors in resected hepatocellular carcinoma: status and correlation with markers of poor prognosis[J]. Histopathology, 2017, 70(3):492-498.
|
[16] |
Tabacchi E, Campana D, Brighi N, et al. 68Ga-DOTANOC PET/CT detects multifocal hepatocellular carcinoma[J]. Clin Nucl Med, 2019, 44(3):238-239.
|
[17] |
Furuta M, Ueno M, Fujimoto A, et al. Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors[J]. J Hepatol, 2017, 66(2):363-373.
|
[18] |
Chianchiano P, Pezhouh MK, Kim A, et al. Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations[J]. Hum Pathol, 2018(72):127-134.
|
[19] |
Tamori A, Nishiguchi S, Nishikawa M, et al. Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma[J]. J Gastroenterol, 2004, 39(11):1063-1068.
|
[20] |
Nomoto S, Yamashita K, Koshikawa K, et al. Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma[J]. Clin Cancer Res, 2002, 8(2):481-487.
|
[21] |
Gao Q, Zhu H, Dong L, et al. Integrated proteogenomic characterization of HBV-related hepatocellular carcinoma[J]. Cell, 2019, 179(2):561-577, e522.
|
[22] |
Duan M, Hao J, Cui S, et al. Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing[J]. Cell Res, 2018, 28(3):359-373.
|
[23] |
Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma[J]. Nat Genet, 2002, 31(4):339-346.
|
[24] |
Morimoto O, Nagano H, Sakon M, et al. Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas[J]. J Hepatol, 2003, 39(2):215-221.
|
[25] |
Zhang Q, Lou Y, Yang J, et al. Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas[J]. Gut, 2019, 68(11): 2019-2031.
|
[26] |
Xu LX, He MH, Dai ZH, et al. Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma[J]. Ann Oncol, 2019, 30(6):990-997.
|
[27] |
Huang M, He M, Guo Y, et al. The influence of immune heterogeneity on the effectiveness of immune checkpoint inhibitors in multifocal hepatocellular carcinomas[J]. Clin Cancer Res, 2020, 26(18):4947-4957.
|
[28] |
Miao R, Luo H, Zhou H, et al. Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis[J]. J Hepatol, 2014, 61(4):840-849.
|
[29] |
Jiang JH, Liu YF, Ke AW, et al. Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing[J]. Hepatology, 2014, 59(6):2216-2227.
|
[30] |
Ikeda A, Shimizu T, Matsumoto Y, et al. Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma[J]. Gastroenterology, 2014, 146(1): 222-232, e235.
|
[31] |
Wada H, Eguchi H, Noda T, et al. Selection criteria for hepatic resection in intermediate-stage (BCLC stage B) multiple hepatocellular carcinoma[J]. Surgery, 2016, 160(5):1227-1235.
|
[32] |
黄镇辉,徐晓艳,蒋小峰,等.人肝癌浸润淋巴细胞的分离培养及其CD8阳性亚群特性研究[J/CD].中华普通外科学文献(电子版), 2020, 14(3):179-183.
|