Chinese practice guidelines for diagnosis and treatment of ischemic-type biliary lesion after liver transplantation

doi:10.3877/cma.j.issn.2095-3232.2024982

Abstract

Abstract:

Over the years of exploration and development，the surgical techniques and prognosis of liver transplantation in China have been significantly improved，resulting in a notable decrease in the prevalence of postoperative complications. However，ischemic-type biliary lesion remain a non-negligible issue.The Third AffiliatedHospital of Sun Yat-sen University formulated and published the "Expert Consensus on the Diagnosis and Treatment of Ischemic-Type Biliary Lesions after Liver Transplantation in Mainland China"in 2015，which has now been updated into aguideline based on current conditions and literature reports. This guideline elaborates in detail on the definition，incidence，pathogenesis，diagnosis，prevention of high-risk factors，and treatment of ischemic-type biliary lesion，aiming to providestandardized and normative guidance for the diagnosis and treatment of ischemic-type biliary lesion after liver transplantation，thereby reducing the rate of re-transplantation and fatality，and to improve the overall quality of life of liver transplant recipients.

Key words: Liver transplantation, Ischemic-type biliary lesion, Diagnosis, Treatment, Donation after brain death, Marginal donor liver, Immunosuppression, Infection

of Organ Transplantation of Chinese Medical Association Branch. Chinese practice guidelines for diagnosis and treatment of ischemic-type biliary lesion after liver transplantation[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(06): 739-748.

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References 75

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推荐强度	证据级别	描述
A	1a	随机对照试验的系统评价
	1b	结果可信区间小的随机对照试验
	1c	显示“全或无效应”的任何证据
B	2a	队列研究的系统评价
	2b	单个的队列研究（包括低质量的随机对照试验，如失访率＞20%者）
	2c	基于患者结局的研究
	3a	病例对照研究的系统评价
	3b	单个病例对照研究
C	4	病例系列报告、低质量队列研究和低质量病例对照研究
D	5	专家意见（即无临床研究支持的仅依据基础研究或临床经验的推测）

推荐强度	证据级别	描述
A	1a	随机对照试验的系统评价
	1b	结果可信区间小的随机对照试验
	1c	显示“全或无效应”的任何证据
B	2a	队列研究的系统评价
	2b	单个的队列研究（包括低质量的随机对照试验，如失访率＞20%者）
	2c	基于患者结局的研究
	3a	病例对照研究的系统评价
	3b	单个病例对照研究
C	4	病例系列报告、低质量队列研究和低质量病例对照研究
D	5	专家意见（即无临床研究支持的仅依据基础研究或临床经验的推测）

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