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Chinese Journal of Hepatic Surgery(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (02): 167-180. doi: 10.3877/cma.j.issn.2095-3232.2025024

• Editorials • Previous Articles     Next Articles

Progress in diagnosis and treatment of hilar cholangiocarcinoma

Chong Zhang1,2, Zongming Zhang1,2,(), Zhuo Liu1,2, Limin Liu1,2, Yue Zhao1,2, Hui Qi1,2   

  1. 1. Department of General Surgery,Beijing Electric Power Hospital,State Grid Corporation,Beijing 100073,China
    2. Key Laboratory of Geriatrics (Hepatobiliary Diseases) of GENERTEC (in preparation),Beijing 100073,China
  • Received:2024-12-08 Online:2025-04-10 Published:2025-03-28
  • Contact: Zongming Zhang

Abstract:

Hilar cholangiocarcinoma (HCCA) is the most common malignant tumor of bile duct.At present, radical resection is the only potential cure method for HCCA.However, the radical resection rate is low and clinical prognosis is poor due to delayed diagnosis and treatment, special anatomical location of the tumor, the characteristics of axial and lateral infiltration along the bile duct and high-risk invasion into surrounding vital vessels, etc.In recent years, along with the improvement of imaging diagnosis level, adequate preoperative evaluation methods, the development of minimally invasive technology, the advancement of surgical technology and perioperative management measures, significant progress has been made in the diagnosis and treatment effect and guaranteeing therapeutic safety for HCCA.Nevertheless,certain problems and challenges remain to be urgently investigated, such as low radical resection rate,controversial surgical timing after reduction of jaundice, difficulty in determining the range of radical resection, and lack of consensus the effect of extended lymph node dissection, etc.In this article, current state and research progress of HCCA classification, staging, early diagnosis, preoperative evaluation,surgical selection, improvement of surgical efficacy, combined vascular resection, lymph node dissection,minimally invasive surgery, liver transplantation and non-surgical treatment were reviewed, aiming to provide reference for further enhancing radical resection rate, prolonging survival time and improving quality of life.

Key words: Hilar cholangiocarinoma, Klatskin tumor, Diagnosis, Therapy, Surgical procedure, Radical resection

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