Hepatectomy is the main treatment for benign and malignant liver diseases. At present, with persistent development of liver surgery and related disciplines, hepatectomy has become a routine procedure in most hepatobiliary and pancreatic disease centers. When surgery enters the era of laparoscopy, laparoscopic hepatectomy has gradually become the main surgical treatment for liver tumors. Accurate perioperative evaluation, intraoperative bleeding control and postoperative individualized management are the keys to successful operation. Among them, intraoperative bleeding control remain a more important topic for surgeons and anesthesiologists in liver surgery. Consequently, it is necessary to explore a more effective and safer technology to minimize intraoperative bleeding during hepatectomy. Currently, low central venous pressure (LCVP) can effectively minimize intraoperative bleeding, reduce the requirement for blood transfusion, and provide a clearer view of surgical field for surgeons, which has been widely applied in clinical practice. However, studies at home and abroad also show that the application of LCVP in hepatectomy remains controversial. Therefore, in this article, relevant principles, specific implementation patterns and the impact of LCVP on vital organs of patients after hepatectomy were reviewed, aiming to provide reference for clinicians to rationally apply LCVP in hepatectomy.