ICG is a commonly-used organic dye in hepatectomy. ICG excretion test can accurately evaluate blood flow distribution and active transport function of the liver, which can be employed to evaluate liver function and predict postoperative liver failure. In addition, ICG fluorescence imaging combined with preoperative imaging data and intraoperative ultrasound can achieve precise tumor location and margin assessment, detect postoperative bile leakage, and assist surgeons to deliver precise intraoperative navigation. At present, certain clinical efficacy has been achieved in the application of ICG in hepatectomy. However, its clinical value remains to be validated by more high-quality research.