Research progress in diagnostic and therapeutic value of exosomes for cholangiocarcinoma

doi:10.3877/cma.j.issn.2095-3232.2026.05.020

Abstract

Abstract:

Cholangiocarcinoma is a malignant tumor with strong invasiveness and poor prognosis. The sensitivity and specificity of existing diagnostic markers are relatively low, and novel methods urgently need to be explored. Exosomes, as cystic vesicles carrying bioactive molecules such as proteins, lipids and non-coding RNAs, play a key role in the progression of cholangiocarcinoma. Proteins, such as B-cell specific Moloney murine leukemia virus integration site 1, liver kinase B1, lipids such as phosphatidylcholine, and non-coding RNAs such as miR-200 family and circ_0000284, are involved in the processes of tumor proliferation, invasion, metastasis and drug resistance. Exosomes in cholangiocarcinoma tissues, bile and blood have specific diagnostic values. Moreover, exosomes can be used as drug carriers for targeted therapy.However, the standardization of exosome separation technology, mechanism and clinical translation still face challenges. Efforts should be made for further breakthroughs to achieve diagnostic and therapeutic potentials.

Key words: Cholangiocarcinoma, Extracellular vesicles, Tumor microenvironment, Diagnostic marker, Therapeutic target

Youwei Li, Dongmei Rong, Zongming Zhang. Research progress in diagnostic and therapeutic value of exosomes for cholangiocarcinoma[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2026, 15(05): 823-830.

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