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中华肝脏外科手术学电子杂志 ›› 2016, Vol. 05 ›› Issue (06) : 409 -412. doi: 10.3877/cma.j.issn.2095-3232.2016.06.015

所属专题: 文献

综述

Nrf2与肝脏缺血-再灌注损伤
刘荣强1, 汪国营1,()   
  1. 1. 510630 广州,中山大学附属第三医院器官移植中心
  • 收稿日期:2016-08-15 出版日期:2016-12-10
  • 通信作者: 汪国营
  • 基金资助:
    国家十二五科技重大专项(2012ZX10002017-005, 2012ZX10002016-023); 广东省科技计划项目(2014B020228003, 2014A020211015); 广东省自然科学基金(2015A030312013, 2015A030313038); 广州市科技计划项目(201400000001-3, 158100076, 2014J4100183)

Nrf2 and hepatic ischemia-reperfusion injury

Rongqiang Liu1, Guoying Wang1()   

  • Received:2016-08-15 Published:2016-12-10
  • Corresponding author: Guoying Wang
引用本文:

刘荣强, 汪国营. Nrf2与肝脏缺血-再灌注损伤[J/OL]. 中华肝脏外科手术学电子杂志, 2016, 05(06): 409-412.

Rongqiang Liu, Guoying Wang. Nrf2 and hepatic ischemia-reperfusion injury[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2016, 05(06): 409-412.

[1]
Ferrari RS, Aandrade CF. Oxidative stress and lung ischemia-reperfusion injury[J]. Oxid Med Cell Longev, 2015:590987.
[2]
Shokeir AA, Barakat N, Hussein AM, et al. Activation of Nrf2 by ischemic preconditioning and sulforaphane in renal ischemia/reperfusion injury: a comparative experimental study[J]. Physiol Res, 2015, 64(3):313-323.
[3]
Takagi T, Kitashoji A, Iwawaki T, et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury[J]. Free Radic Biol Med, 2014(72):124-133.
[4]
Katsumata Y, Shinmura K, Sugiura Y, et al. Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2[J]. Hypertension, 2014, 63(1):80-87.
[5]
Tanaka Y, Maher JM, Chen C, et al. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice[J]. Mol Pharmacol, 2007, 71(3):817-825.
[6]
Moi P, Chan K, Asunis I, et al. Isolation of NF-E2-related factor 2(Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region [J]. Proc Natl Acad Sci U S A, 1994, 91(21):9926-9930.
[7]
Gao B, Doan A, Hybertson BM. The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders[J]. Clin Pharmacol, 2014(6):19-34.
[8]
Nioi P, Nguyen T, Sherratt PJ, et al. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation[J]. Mol Cell Biol, 2005, 25(24):10895-10906.
[9]
Wang H, Liu K, Geng M, et al. RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2[J]. Cancer Res, 2013, 73(10):3097-3108.
[10]
Wu J, Wang H, Tang X. Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha[J]. Biochem Biophys Res Commun, 2014, 452(3):554-559.
[11]
Namani A, Li Y, Wang XJ, et al. Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer[J]. Biochim Biophys Acta, 2014, 1843(9):1875-1885.
[12]
Uruno A, Motohashi H. The Keap1-Nrf2 system as an in vivo sensor for electrophiles[J]. Nitric Oxide, 2011, 25(2):153-160.
[13]
Taguchi K, Fujikawa N, Komatsu M, et al. Keap1 degradation by autophagy for the maintenance of redox homeostasis[J]. Proc Natl Acad Sci U S A, 2012, 109(34):13561-13566.
[14]
Ogborne RM, Rushworth SA, O'Connell MA. Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2[J]. Biochem Biophys Res Commun, 2008, 373(4):584-588.
[15]
Ichihara S, Yamada Y, Liu F, et al. Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response[J]. Arterioscler Thromb Vasc Biol, 2010, 30(8):1553-1561.
[16]
Yu JB, Shi J, Zhang Y, et al. Electroacupuncture ameliorates acute renal injury in lipopolysaccharide-stimulated rabbits via induction of HO-1 through the PI3K/Akt/Nrf2 pathways[J]. PLoS One, 2015, 10(11):e0141622.
[17]
Ma Q, Battelli L, Hubbs AF. Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2[J]. Am J Pathol, 2006, 168(6):1960-1974.
[18]
Thimmulappa RK, Lee H, Rangasamy T, et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis[J]. J Clin Invest, 2006, 116(4):984-995.
[19]
Kong X, Thimmulappa R, Craciun F, et al. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis[J]. Am J Respir Crit Care Med, 2011, 184(8):928-938.
[20]
Morito N, Yoh K, Itoh K, et al. Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels[J]. Oncogene, 2003, 22(58):9275-9281.
[21]
Bhakkiyalakshmi E, Shalini D, Sekar TV, et al. Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2[J]. Br J Pharmacol, 2014, 171(7):1747-1757.
[22]
Luna-Vargas MP, Chipuk JE. The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane[J]. FEBS J, 2016, 283(14):2676-2689.
[23]
Lu YF, Liu J, Wu KC, et al. Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice[J]. PLoS One, 2014, 9(3):e93013.
[24]
Kode A, Rajendrasozhan S, Caito S, et al. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells[J]. Am J Physiol Lung Cell Mol Physiol, 2008, 294(3):L478-488.
[25]
Braun S, Hanselmann C, Gassmann MG, et al. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound[J]. Mol Cell Biol, 2002, 22(15):5492-5505.
[26]
Okouchi M, Okayama N, Alexander JS, et al. NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia-induced brain endothelial cell apoptosis[J]. Curr Neurovasc Res, 2006, 3(4):249-261.
[27]
Schaedler S, Krause J, Himmelsbach K, et al. Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2[J]. J Biol Chem, 2010, 285(52):41074-41086.
[28]
Carvajal-Yepes M, Himmelsbach K, Schaedler S, et al. Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins[J]. J Biol Chem, 2011, 286(11):8941-8951.
[29]
Weigand K, Brost S, Steinebrunner N, et al. Ischemia/Reperfusion injury in liver surgery and transplantation: pathophysiology[J]. HPB Surg, 2012:176723.
[30]
Kim HY, Kim SJ, Lee SM. Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion[J]. FEBS J, 2015, 282(2):259-270.
[31]
Leal AJ, Tannuri AC, Belon AR, et al. Effects of ischemic preconditioning in a pig model of large-for-size liver transplantation[J]. Clinics, 2015, 70(2):126-135.
[32]
Behrends M, Hirose R, Serkova NJ, et al. Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats[J]. Liver Int, 2006, 26(6):734-741.
[33]
Kudoh K, Uchinami H, Yoshioka M, et al. Nrf2 activation protects the liver from ischemia/reperfusion injury in mice[J]. Ann Surg, 2014, 260(1):118-127.
[34]
Lee LY, Harberg C, Matkowskyj KA, et al. Overactivation of the nuclear factor (erythroid-derived 2)-like 2-antioxidant response element pathway in hepatocytes decreases hepatic ischemia/reperfusion injury in mice[J]. Liver Transpl, 2016, 22(1):91-102.
[35]
Chi X, Zhang R, Shen N, et al. Sulforaphane reduces apoptosis and oncosis along with protecting liver injury-induced ischemic reperfusion by activating the Nrf2/ARE pathway[J]. Hepatol Int, 2015, 9(2):321-329.
[36]
Shimada S, Fukai M, Wakayama K, et al. Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver[J]. Surg Today, 2015, 45(7):892-903.
[37]
Joe Y, Zheng M, Kim HJ, et al. Cilostazol attenuates murine hepatic ischemia and reperfusion injury via heme oxygenase-dependent activation of mitochondrial biogenesis[J]. Am J Physiol Gastrointest Liver Physiol, 2015, 309(1):G21-29.
[38]
Morales P, Vargas R, Videla LA, et al. Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol[J]. Food Funct, 2014, 5(2):243-250.
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