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中华肝脏外科手术学电子杂志 ›› 2021, Vol. 10 ›› Issue (04) : 418 -422. doi: 10.3877/cma.j.issn.2095-3232.2021.04.017

临床研究

鱼刺致肝脏炎性假瘤误诊1例并文献复习
庄宝鼎1, 木斯他巴·买买提热依木2, 卢逸1, 李彦杰1, 苏日顺1, 邓美海1, 徐见亮1,()   
  1. 1. 510630 广州,中山大学附属第三医院肝胆外科
    2. 844000 新疆维吾尔自治区喀什地区第一人民医院普通外科
  • 收稿日期:2021-04-28 出版日期:2021-08-18
  • 通信作者: 徐见亮
  • 基金资助:
    广东省科技创新战略专项资金(2018A030313608); 广东省中医药管理局基金(20211085)

Misdiagnosis of inflammatory pseudotumor of liver caused by fishbone: one case report and literature review

Baoding Zhuang1, Maimaitireyimu Musitaba·2, Yi Lu1, Yanjie Li1, Rishun Su1, Meihai Deng1, Jianliang Xu1,()   

  1. 1. Department of Hepatobiliary Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
    2. Department of General Surgery, the First People's Hospital of Kashgar, Kashgar 844000, China
  • Received:2021-04-28 Published:2021-08-18
  • Corresponding author: Jianliang Xu
引用本文:

庄宝鼎, 木斯他巴·买买提热依木, 卢逸, 李彦杰, 苏日顺, 邓美海, 徐见亮. 鱼刺致肝脏炎性假瘤误诊1例并文献复习[J]. 中华肝脏外科手术学电子杂志, 2021, 10(04): 418-422.

Baoding Zhuang, Maimaitireyimu Musitaba·, Yi Lu, Yanjie Li, Rishun Su, Meihai Deng, Jianliang Xu. Misdiagnosis of inflammatory pseudotumor of liver caused by fishbone: one case report and literature review[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2021, 10(04): 418-422.

目的

探讨鱼刺致肝脏炎性假瘤(IPT)的诊治特点。

方法

回顾性分析2015年8月中山大学附属第三医院收治的1例鱼刺致肝脏IPT患者临床资料。患者男,51岁。患者签署知情同意书,符合医学伦理规定。分析并复习相关文献病例的临床病理资料,包括病史、诊治经过及预后随访等,总结此类罕见病例的诊治特点。

结果

患者因"反复右上腹痛3年余,加重伴胃纳差1个月"就诊。入院后实验室检查发现WBC、GGT、C-反应蛋白和红细胞沉降率等均升高。腹部超声、CT、MRI均未能排除肝内胆管细胞癌可能。超声引导经皮肝穿刺活检术诊断肝内肿物为炎性病变。经抗感染治疗后肝脏占位未见明显缩小,且临床症状仍反复。遂于2015年12月15日开腹探查,发现鱼刺从胃窦部进入肝左叶,行肝部分切除、鱼刺取出、胆囊切除、广泛粘连松解及胃壁穿孔修补术。术后病理证实肝脏肿物为肝脏IPT。出院1个月患者一般状态良好,实验室各项检测结果均恢复正常。复查腹部增强CT显示手术部位未见残留病灶。

结论

鱼刺等异物致肝脏IPT是一种罕见肝内占位性病变,影像学表现易误诊为肿瘤,病理活检对于IPT的诊断有重要作用,手术取出异物并修补消化道穿孔是有效的治疗手段。

Objective

To explore the diagnostic and treatment characteristics of inflammatory pseudotumor (IPT) of the liver caused by fishbone.

Methods

Clinical data of 1 patient with IPT of the liver caused by fishbone admitted to the Third Affiliated Hospital of Sun Yat-sen University in August 2015 were retrospectively analyzed. The male patient aged 51 years. The informed consent of the patient was obtained and the local ethical committee approval was received. The clinicopathological data of relevant literature were reviewed and analyzed including medical history, diagnosis and treatment, clinical prognosis and follow-up. The diagnostic and treatment characteristics of this rare case were summarized.

Results

The patient was hospitalized due to "recurrent right upper abdominal pain for more than 3 years, which was aggravated complicated with anorexia for 1 month". Laboratory examination upon admission indicated that WBC, GGT, C-reactive protein and erythrocyte sedimentation rate were increased. The possibility of intrahepatic cholangiocarcinoma could not be excluded by abdominal ultrasound, CT scan and MRI. The intrahepatic tumor was diagnosed as an inflammatory lesion by ultrasound-guided percutaneous liver biopsy. After anti-infection treatment, the liver mass was not significantly reduced, and clinical symptoms still recurred. On December 15, 2015, abdominal exploration was performed on the patient and a fishbone was found invaded into the left liver lobe from the antrum. Thus partial hepatectomy was conducted, the fishbone was removed, cholecystectomy was carried out, followed by extensive adhesion management and gastric wall perforation repair. The diagnosis of IPT of the liver was confirmed by postoperative pathological examination. At 1 month after discharge, the patient was generally in good condition, and all the laboratory test results were normal. Abdominal enhanced CT scan showed no residual lesion at the surgical site.

Conclusions

IPT of the liver caused by foreign matter, such as fishbone, is a rare space-occupying intrahepatic lesion, which is likely to be misdiagnosed as tumors by the imaging examination. Pathological biopsy plays a pivotal role in the diagnosis of IPT. Surgical removal of foreign matter and repair of perforated digestive tract are effective therapies.

图1 一例鱼刺致肝脏IPT患者手术前后情况
表1 本组1例及检索文献报道的鱼刺致IPT误诊患者资料
[1]
Bandeira-de-Mello RG, Bondar G, Schneider E, et al. Pyogenic liver abscess secondary to foreign body (fish bone) treated by laparoscopy: a case report[J]. Ann Hepatol, 2018, 17(1):169-173.
[2]
Li J, Zhao D, Lei L, et al. Liver abscess caused by ingestion of fishbone: a case report[J]. Medicine, 2019, 98(34):e16835.
[3]
de la Vega M, Rivero JC, Ruíz L, et al. A fish bone in the liver[J]. Lancet, 2001, 358(9286):982.
[4]
Theodoropoulou A, Roussomoustakaki M, Michalodimitrakis MN, et al. Fatal hepatic abscess caused by a fish bone[J]. Lancet, 2002, 359(9310):977.
[5]
Perera MTPR, Wijesuriya SRE, Kumarage SK, et al. Inflammatory pseudotumour of the liver caused by a migrated fish bone[J]. Ceylon Med J, 2007, 52(4):141-142.
[6]
Srinivasan UP, Duraisamy AB, Ilango S, et al. Inflammatory pseudotumor of liver secondary to migrated fishbone: a rare cause with an unusual presentation[J]. Ann Gastroenterol, 2013, 26(1):84-86.
[7]
Yin L, Zhu B, Lu XY, et al. Misdiagnosing hepatic inflammatory pseudotumor as hepatocellular carcinoma: a case report[J]. 2017, 1(2):76-78.
[8]
肖杨,吴泓. 误食鱼刺致继发肝脓肿误诊为肝转移瘤1例报道[J]. 中国普外基础与临床杂志, 2018, 25(1):118-119.
[9]
Park JY, Choi MS, Lim YS, et al. Clinical features, image findings, and prognosis of inflammatory pseudotumor of the liver: a multicenter experience of 45 cases[J]. Gut Liver, 2014, 8(1):58-63.
[10]
Dangoisse C, Laterre PF. Erratum: tracking the foreign body, a rare cause of hepatic abscess[J]. BMC Gastroenterol, 2015(15):27.
[11]
Matrella F, Lhuaire M, Piardi T, et al. Liver hilar abscesses secondary to gastrointestinal perforation by ingested fish bones: surgical management of two cases[J]. Hepatobiliary Surg Nutr, 2014, 3(3): 156-162.
[12]
Ede C, Sobnach S, Kahn D, et al. Enterohepatic migration of fish bone resulting in liver abscess[J]. Case Rep Surg, 2015:238342.
[13]
Peixoto A, Gonçalves R, Macedo G. Liver abscess associated sepsis caused by fish bone ingestion[J]. GE Port J Gastroenterol, 2016, 23(6):322-323.
[14]
Kai K, Matsuyama S, Ohtsuka T, et al. Multiple inflammatory pseudotumor of the liver, mimicking cholangiocarcinoma with tumor embolus in the hepatic vein: report of a case[J]. Surg Today, 2007, 37(6):530-533.
[15]
Li SQ, Liang LJ, Peng BG, et al. Outcomes of liver resection for intrahepatic stones: a comparative study of unilateral versus bilateral disease[J]. Ann Surg, 2012, 255(5):946-953.
[16]
Biecker E, Zimmermann A, Dufour JF. Spontaneous regression of an inflammatory pseudotumor of the liver[J]. Z Gastroenterol, 2003, 41(10):991-994.
[17]
Yin L, Zhu B, Lu XY, et al. Misdiagnosing hepatic inflammatory pseudotumor as hepatocellular carcinoma: a case report[J]. JGH Open, 2017, 1(2):76-78.
[18]
Inaba K, Suzuki S, Yokoi Y, et al. Hepatic inflammatory pseudotumor mimicking intrahepatic cholangiocarcinoma: report of a case[J]. Surg Today, 2003, 33(9):714-717.
[19]
Matsuo Y, Sato M, Shibata T, et al. Inflammatory pseudotumor of the liver diagnosed as metastatic liver tumor in a patient with a gastrointestinal stromal tumor of the rectum: report of a case[J]. World J Surg Oncol, 2014(12):140.
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