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中华肝脏外科手术学电子杂志 ›› 2022, Vol. 11 ›› Issue (05) : 524 -527. doi: 10.3877/cma.j.issn.2095-3232.2022.05.019

所属专题: 综述

病例报告

局部进展期胰腺癌综合治疗一例
张继成1, 赵过超1, 张磊1, 施晨晔1, 吴莉莉2, 王明亮3, 张轶群4, 刘凌晓5, 纪元6, 周宇红7, 王单松1, 楼文晖1, 吴文川1,()   
  1. 1. 200032 上海,复旦大学附属中山医院普通外科
    2. 200032 上海,复旦大学附属中山医院放疗科
    3. 200032 上海,复旦大学附属中山医院影像医学科
    4. 200032 上海,复旦大学附属中山医院内镜中心
    5. 200032 上海,复旦大学附属中山医院介入科
    6. 200032 上海,复旦大学附属中山医院病理科
    7. 200032 上海,复旦大学附属中山医院肿瘤内科
  • 收稿日期:2022-05-16 出版日期:2022-10-10
  • 通信作者: 吴文川
  • 基金资助:
    国家自然科学基金(81773068); 上海市青年科技英才扬帆计划(21YF1407100)

Comprehensive managements for locally advanced pancreatic cancer: report of one case

Jicheng Zhang1, Guochao Zhao1, Lei Zhang1   

  • Received:2022-05-16 Published:2022-10-10
引用本文:

张继成, 赵过超, 张磊, 施晨晔, 吴莉莉, 王明亮, 张轶群, 刘凌晓, 纪元, 周宇红, 王单松, 楼文晖, 吴文川. 局部进展期胰腺癌综合治疗一例[J/OL]. 中华肝脏外科手术学电子杂志, 2022, 11(05): 524-527.

Jicheng Zhang, Guochao Zhao, Lei Zhang. Comprehensive managements for locally advanced pancreatic cancer: report of one case[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(05): 524-527.

胰腺癌恶性程度高,预后差,5年生存率低于10%,预计到2030年将成为全球第二大致死癌症[1,2,3]。80%~85%的患者在确诊时已发展为不可切除或转移阶段,丧失了手术机会,即使施行了根治性切除,术后5年生存率也仅仅10%~15%,绝大多数患者均要面临术后复发转移的现实困境[2]。因此,不管确诊时胰腺癌是否可切除,均需要综合治疗。不同个体在疾病进展过程中也要面临各种状态并需要进行治疗决策,治疗手段包括手术、放疗及化疗、靶向治疗和免疫疗法等近年也取得了一定进展[4,5,6]。本文通过回顾1例局部进展期胰腺癌综合治疗过程,分享笔者在治疗决策方面的体会和思考。

图1 一例局部进展期胰腺癌患者第一次手术前后影像学检查注:a、b分别为术前增强CT和MRI示胰头钩突肿块包绕肠系膜上动、静脉;c为术后2年半复查MRI示胰腺钩突肿瘤明显缩小,未发现肿瘤侵犯包绕肠系膜上动、静脉
图2 一例局部进展期胰腺癌患者第二次手术前后影像学检查注:a、b分别为术前增强CT示结肠肝曲、盆底均可见增强病灶;c为术后9个月增强MRI示胰头钩突肿块明显缩小,未见新发转移病灶
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