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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (05) : 499 -503. doi: 10.3877/cma.j.issn.2095-3232.2023.05.006

专家论坛

原发性肝癌的分子诊断
王楚风, 蒋安()   
  1. 710004 西安交通大学第二附属医院移植外科
  • 收稿日期:2023-07-10 出版日期:2023-10-10
  • 通信作者: 蒋安
  • 基金资助:
    陕西省重点研发计划(2022SF-372)

Molecular diagnosis of primary liver cancer

Chufeng Wang, An Jiang()   

  • Received:2023-07-10 Published:2023-10-10
  • Corresponding author: An Jiang
引用本文:

王楚风, 蒋安. 原发性肝癌的分子诊断[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 499-503.

Chufeng Wang, An Jiang. Molecular diagnosis of primary liver cancer[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 499-503.

原发性肝癌(肝癌)发病率呈现上升趋势,病死率位居全球第4位[1,2]。肝癌具有起病隐匿、进展速度快、异质性强、病理机制复杂、预后差等特点,我国肝癌发生率及病死率均超过全球平均水平的50%,发现时往往处于晚期,失去手术机会。因此,探索肝癌发生的分子机制、针对肝癌的早发现、早筛查、早诊断对于提高肝癌患者的生存率和生活质量有重要意义。肝穿刺活检虽然是肝癌确诊的金标准,但面对分化程度较好的肝癌组织时容易误诊。另外,患者的依从性以及肝穿刺可能发生并发症也决定了肝穿刺活检并不是肝癌早期诊断的首选。因此,寻找肝癌早期诊断方法,对肝癌患者的早期筛查、早期诊断及生存率提高有重大意义。

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