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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (06) : 619 -623. doi: 10.3877/cma.j.issn.2095-3232.2023.06.006

临床研究

外伤性脾破裂腹腔镜脾切除术患者中转开腹风险预测模型构建
林文斌, 郑泽源, 郑文能, 郁毅刚()   
  1. 363000 福建省漳州市,第九〇九医院(厦门大学附属东南医院)急诊科
  • 收稿日期:2023-09-05 出版日期:2023-12-10
  • 通信作者: 郁毅刚
  • 基金资助:
    军队后勤科研重大项目(BLB18J006)

Construction of prediction model for risk of conversion to open surgery in patients with traumatic splenic rupture undergoing laparoscopic splenectomy

Wenbin Lin, Zeyuan Zheng, Wenneng Zheng, Yigang Yu()   

  1. Department of Emergency, The 909th Hospital (Dongnan Hospital of Xiamen University), Zhangzhou 363000, China
  • Received:2023-09-05 Published:2023-12-10
  • Corresponding author: Yigang Yu
引用本文:

林文斌, 郑泽源, 郑文能, 郁毅刚. 外伤性脾破裂腹腔镜脾切除术患者中转开腹风险预测模型构建[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 619-623.

Wenbin Lin, Zeyuan Zheng, Wenneng Zheng, Yigang Yu. Construction of prediction model for risk of conversion to open surgery in patients with traumatic splenic rupture undergoing laparoscopic splenectomy[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 619-623.

目的

探讨外伤性脾破裂腹腔镜脾切除术患者中转开腹的影响因素,并构建风险预测模型。

方法

回顾性分析2019年6月至2022年6月第九〇九医院收治的62例外伤性脾破裂患者临床资料。患者均签署知情同意书,符合医学伦理学规定。其中男47例,女15例;年龄29~51岁,中位年龄41岁。Ⅱ级脾外伤17例,Ⅲ级脾外伤35例,Ⅳ级脾外伤10例。患者术中中转开腹14例。术中中转开腹影响因素分析采用χ2检验和多因素Logistic回归分析,构建中转开腹预测模型,绘制ROC曲线分析该模型对中转开腹风险的预测效能。

结果

单因素分析显示,BMI≥27 kg/m2、损伤分级Ⅳ级、高年资主治医师主刀、术中脾损伤、暴露不佳的患者中转开腹率明显升高(χ2=7.468,15.336,5.124,15.849,12.111;P<0.05)。多因素分析显示,高年资主治医师主刀、术中脾损伤、暴露不佳是术中中转开腹的独立影响因素(HR=17.717,20.764,10.343;P<0.05)。以术中中转开腹为因变量,主刀医师年资、术中脾损伤、暴露不佳分别为自变量,构建术中中转开腹预测模型为Logit(P)=-18.980+2.875×X1+3.033×X2+2.336×X3(X1为高年资主治医师主刀,X2为术中脾损伤,X3为暴露不佳)。该模型预测中转开腹ROC曲线下面积为0.925,敏感度为0.857,特异度为0.854。

结论

术者经验不足、术中脾损伤、暴露不佳是脾破裂患者腹腔镜手术失败的独立影响因素,通过构建模型可筛选适合腹腔镜手术的患者。

Objective

To investigate the influencing factors of conversion to open surgery in patients with traumatic splenic rupture undergoing laparoscopic splenectomy and to construct a risk prediction model.

Methods

Clinical data of 62 patients with traumatic splenic rupture admitted to The 909th Hospital from June 2019 to June 2022 were retrospectively analyzed.The informed consents of all patients were obtained and the local ethical committee approval was received. Among them, 47 patients were male and 15 female,aged from 29 to 51 years, with a median age of 41 years. 17 patients were diagnosed with grade Ⅱ splenic trauma, 35 cases of grade Ⅲ splenic trauma and 10 cases of grade Ⅳ splenic trauma. Intraoperative conversion to open surgery was performed in 14 patients. The influencing factors of intraoperative conversion to open surgery were analyzed by Chi-square test and multivariate Logistic regression analysis. The prediction model for risk of conversion to open surgery was constructed. The ROC curve was drawn to analyze the prediction efficiency of this model for the risk of conversion to open surgery.

Results

Univariate analysis showed that the conversion rate in patients with BMI≥27 kg/m2, grade Ⅳ trauma, experienced attending physician as chief surgeon, intraoperative splenic injury and poor exposure was significantly increased (χ2=7.468, 15.336, 5.124, 15.849, 12.111; P<0.05). Multivariate analysis demonstrated that experienced chief surgeon, intraoperative splenic injury and poor exposure were the independent influencing factors for intraoperative conversion to open surgery (HR=17.717, 20.764, 10.343; P<0.05). Taking intraoperative conversion to open surgery as the dependent variable, and experienced chief surgeon, intraoperative splenic injury and poor exposure as the independent variables, the prediction model for risk of intraoperative conversion to open surgery was constructed as Logit(P)=-18.980+2.875×X1+3.033×X2+2.336×X3 (X1 was experienced chief surgeon, X2 was intraoperative splenic injury, X3 was poor exposure). The area under the ROC curve (AUC) of this prediction model was 0.925, the sensitivity was 0.857 and the specificity was 0.854.

Conclusions

Insufficient experience of chief surgeon, intraoperative splenic injury and poor exposure are the independent influencing factors for the failure of laparoscopic surgery in patients with splenic rupture. Eligible patients for laparoscopic surgery can be screened by constructing risk prediction models.

表1 62例脾外伤患者中转开腹的单因素分析
表2 62例脾外伤患者中转开腹的多因素分析
图1 脾外伤患者中转开腹预测模型的ROC曲线
[1]
Radwan I, Magdy Khattab M, Mahmoud AR, et al. Systematic review of spontaneous splenic rupture in dengue-infected patients[J]. Rev Med Virol, 2019, 29(2):e2029.
[2]
陶亮, 谢志杰, 高书峰, 等. 62例创伤性脾破裂行腹腔镜脾切除的临床经验[J]. 中华普通外科杂志, 2019, 34(5):428-430.
[3]
Loera JM, Khot SC, Bachim A, et al. Rupture of chronic post-traumatic splenic cyst in child with history of abuse[J]. Am Surg, 2023, 89(4):1069-1072.
[4]
危志远, 刘珞, 傅志雄, 等. 脾外伤分级评估及诊治现状[J/OL]. 中华肝脏外科手术学电子杂志, 2022, 11(1):1-4.
[5]
周志涛, 范隼, 何伟良, 等. 腹腔镜脾切除术在外伤性脾破裂中的应用价值[J/OL]. 中华肝脏外科手术学电子杂志, 2019, 8(6):522-526.
[6]
中华医学会外科学分会脾功能与脾脏外科学组. 脾脏损伤治疗方式的专家共识(2014版)[J/CD]. 中华普通外科学文献(电子版), 2015, 14(2):83-85.
[7]
Anand A, Khurana S, Ateriya N, et al. Sudden death due to non-traumatic rupture of splenic artery aneurysm[J]. Med Leg J, 2022, 90(2):76-78.
[8]
Hsia K, Johnson J, Rice D. Splenomegaly, non-traumatic splenic rupture, and pancytopenia in patient with human granulocytic anaplasmosis[J]. R I Med J, 2021, 104(2):60-62.
[9]
戴敏, 殷杰, 张德进, 等. 腹腔镜下脾切除术治疗外伤性脾破裂的Meta分析[J]. 腹部外科, 2019, 32(2):108-111.
[10]
杨燕茹, 王琳, 吴安琪. 腹腔镜引导二级脾蒂离断切脾术在创伤性脾损伤患者中的临床效果和价值[J]. 中华全科医学, 2021, 19(1):35-37; 35-37, 58.
[11]
Birindelli A, Martin M, Khan M, et al. Laparoscopic splenectomy as a definitive management option for high-grade traumatic splenic injury when non operative management is not feasible or failed: a 5-year experience from a level one trauma center with minimally invasive surgery expertise[J]. Updates Surg, 2021, 73(4):1515-1531.
[12]
黄洪军, 吴志明, 孟兴成, 等. 右侧卧位与仰卧位在急诊腹腔镜下治疗外伤性脾破裂的手术效果比较[J]. 肝胆胰外科杂志, 2022, 34(5):295-298.
[13]
Rehman S, Hajibandeh S, Hajibandeh S. A systematic review and meta-analysis of anterior versus lateral approach for laparoscopic splenectomy[J]. Surg Laparosc Endosc Percutan Tech, 2019, 29(4): 233-241.
[14]
范瑞芳, 肖毅, 许树林, 等. 二级脾蒂精准离断法腹腔镜脾切除术及开腹脾切除术治疗创伤性脾破裂[J]. 西北国防医学杂志, 2019, 40(12):741-746.
[15]
陈翔, 刘承远, 李佳伟, 等. 手助腹腔镜脾切除术治疗创伤性脾破裂临床分析[J].创伤外科杂志, 2018, 20(12):903-905.
[16]
陈晶, 张悦, 杨雨, 等. 程序化腹腔镜脾切除或脾部分切除术在创伤性脾破裂诊治中的应用[J]. 中华普通外科杂志, 2018, 33(10):878-879.
[17]
Radkowiak D, Zychowicz A, Wysocki M, et al. Quest for the optimal technique of laparoscopic splenectomy-vessels first or hilar transection?[J]. Wideochir Inne Tech Maloinwazyjne, 2018, 13(4): 460-468.
[18]
赖莉, 彭方毅, 苏松, 等. 机器人与腹腔镜脾切除术治疗非创伤性脾脏疾病效果比较的Meta分析[J]. 临床肝胆病杂志, 2019, 35(10):2281-2285.
[19]
Wu LF, Xiang XX, Bai DS, et al. Novel noninvasive liver fibrotic markers to predict postoperative re-bleeding after laparoscopic splenectomy and azygoportal disconnection: a 1-year prospective study[J]. Surg Endosc, 2021, 35(11):6158-6165.
[20]
姚志成,黄河,邬杰忠,刘波.脾动脉先行的五步法腹腔镜脾切除术[J/OL].中华肝脏外科手术学电子杂志, 2021, 10(1):112.
[21]
李后俊, 周正武, 刘晓林. 手术治疗与保守治疗创伤性脾破裂的临床效果比较[J].临床外科杂志, 2019, 27(11):992-994.
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