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中华肝脏外科手术学电子杂志 doi: 10.3877/cma.j.issn.2095-3232.2024999

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胆囊癌的免疫靶向治疗进展
陈伟杰1, 何小东1,()   
  1. 1. 100730 中国医学科学院北京协和医院基本外科
  • 收稿日期:2024-06-08
  • 通信作者: 何小东
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目(2017-I2M-4-003,2021-I2M-C&T-B-019); 中华医学会基金(zyj201912)

Progress in immunotargeted therapy for gallbladder cancer

Weijie Chen1, Xiaodong He1,()   

  1. 1. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2024-06-08
  • Corresponding author: Xiaodong He
引用本文:

陈伟杰, 何小东. 胆囊癌的免疫靶向治疗进展[J]. 中华肝脏外科手术学电子杂志, doi: 10.3877/cma.j.issn.2095-3232.2024999.

Weijie Chen, Xiaodong He. Progress in immunotargeted therapy for gallbladder cancer[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), doi: 10.3877/cma.j.issn.2095-3232.2024999.

胆囊癌是一种罕见但具有高度侵袭性和恶性转移潜力的肿瘤。传统的治疗方法如手术切除、化疗和放疗在提高患者生存率方面存在一定的局限性。近年来,免疫靶向治疗作为一种新的治疗策略逐渐受到关注。本文综述了近年来关于胆囊癌免疫靶向治疗的研究进展。免疫治疗通过激活患者自身的免疫系统来抑制肿瘤生长和扩散。靶向治疗则针对某些靶点在胆囊癌治疗中显示出一定的疗效。然而,目前的免疫靶向治疗仍存在一些挑战,如免疫耐受性、免疫逃逸和免疫相关不良事件等。因此,进一步的研究和临床试验仍然需要进行,以提高胆囊癌患者的治疗效果和生存率。

Gallbladder cancer is a rare tumor with high invasiveness and malignant metastatic potential. Traditional treatments, such as surgical resection, chemotherapy and radiotherapy, have certain limitations in improving the survival rate of patients. As a novel therapeutic strategy, immunotargeted therapy has attracted widespread attention in recent years. In this article, recent research progress in immunotargeted therapy for gallbladder cancer was reviewed. Immunotherapy can inhibit tumor growth and metastasis by activating the patients' immune system. Targeted therapy has shown certain efficacy in the treatment of gallbladder cancer via several targets. However, challenges still exist in immunotargeted therapy, such as immune tolerance, immune escape and immune-related adverse events, etc. Therefore, subsequent researches and clinical trials should be carried out to improve the therapeutic effect and survival rate of patients with gallbladder cancer.

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