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中华肝脏外科手术学电子杂志 ›› 2025, Vol. 14 ›› Issue (04) : 536 -542. doi: 10.3877/cma.j.issn.2095-3232.2025.04.006

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光动力疗法在晚期胆管癌中应用研究进展
董思帆1, 安仕琪1, 刘起帆1, 王楚风1, 蒋安2,()   
  1. 1710016 西安交通大学医学部
    2710004 西安交通大学第二附属医院肝胆胰与肝移植外科
  • 收稿日期:2025-02-16 出版日期:2025-08-10
  • 通信作者: 蒋安
  • 基金资助:
    陕西省重点研发计划项目(2022SF-372)

Research progress in photodynamic therapy in advanced cholangiocarcinoma

Sifan Dong1, Shiqi An1, Qifan Liu1, Chufeng Wang1, An Jiang2,()   

  1. 1Xi'an Jiaotong University Health Science Center, Xi'an 710016, China
    2Department of Hepatobiliary, Pancreatic and Liver Transplantation of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China
  • Received:2025-02-16 Published:2025-08-10
  • Corresponding author: An Jiang
引用本文:

董思帆, 安仕琪, 刘起帆, 王楚风, 蒋安. 光动力疗法在晚期胆管癌中应用研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(04): 536-542.

Sifan Dong, Shiqi An, Qifan Liu, Chufeng Wang, An Jiang. Research progress in photodynamic therapy in advanced cholangiocarcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 14(04): 536-542.

光动力疗法(PDT)是目前临床上一种新型的治疗方法,被广泛应用于治疗皮肤癌、肝癌、胆管癌等,可以显著提高患者的生活质量。PDT利用肿瘤对光敏剂的高吸收特性,使肿瘤细胞光敏剂浓度高于周围组织,在可见光的照射下,发生光氧化还原反应,诱导肿瘤细胞死亡。胆管癌在国内的发病率日渐上升,胆管癌大多数早期无任何症状,随着疾病的发展,患者表现为不明原因的乏力,食欲减退和体重下降,疾病末期胆管内胆汁淤积,出现黄疸,降低了患者的生存质量。手术治疗的意义不大,其他疗法的效果也往往有限,而PDT作为一种新型治疗方式,对胆管癌具有积极的治疗价值。本文通过介绍PDT及其联合其他治疗方法前景,为临床提供理论基础。

Photodynamic therapy (PDT) is a novel treatment in clinical practice, which has been widely employed to treat skin cancer, liver cancer and cholangiocarcinoma, etc. PDT can significantly enhance the quality of life of patients. It utilizes high absorption of photosensitizer by tumors to make the photosensitizer concentration in tumor cells higher than that of surrounding tissues. Under the irradiation of visible light, photo-redox reaction occurs, which induces the death of tumor cells. The incidence of cholangiocarcinoma is on the rise in China. Most cholangiocarcinoma patients have no symptoms at the early stage. As the disease progresses, patients suffer from unexplained fatigue, lack of appetite and weight loss, and bile duct obstruction and jaundice will occur at the advanced stage, which reduces the quality of life of patients. Surgery and other therapies yield low efficacy. PDT, as a novel treatment, has positive therapeutic value for cholangiocarcinoma. In this article, the prospect of PDT and its combination with alternative therapies was illustrated, aiming to provide theoretical basis for clinicians.

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