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中华肝脏外科手术学电子杂志 ›› 2025, Vol. 14 ›› Issue (04) : 528 -535. doi: 10.3877/cma.j.issn.2095-3232.2025.04.005

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低中心静脉压技术及其在腹腔镜肝切除术中应用进展
麦吾兰江·麦麦提, 吐尔洪江·吐逊()   
  1. 830054 乌鲁木齐,新疆医科大学第一附属医院消化血管外科中心 肝脏·腹腔镜外科
  • 收稿日期:2025-02-03 出版日期:2025-08-10
  • 通信作者: 吐尔洪江·吐逊
  • 基金资助:
    国家自然科学基金(82260411,82270632)

Low central venous pressure technique and its application progress in laparoscopic hepatectomy

Maimaiti Maiwulanjiang·, Tuxun Tuerhongjiang·()   

  1. Department of Liver and Laparoscopic Surgery, Digestive Vascular Surgery Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Received:2025-02-03 Published:2025-08-10
  • Corresponding author: Tuxun Tuerhongjiang·
引用本文:

麦吾兰江·麦麦提, 吐尔洪江·吐逊. 低中心静脉压技术及其在腹腔镜肝切除术中应用进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(04): 528-535.

Maimaiti Maiwulanjiang·, Tuxun Tuerhongjiang·. Low central venous pressure technique and its application progress in laparoscopic hepatectomy[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 14(04): 528-535.

肝脏切除手术属于肝脏良恶性疾病治疗的主要方式,目前随着肝脏外科技术和相关学科的不断发展,肝切除术成为大多数肝胆胰中心的常规术式。随着外科手术治疗进入腔镜时代,腹腔镜肝切除术现在逐渐成为肝脏肿瘤外科治疗主要方式。围手术期精准评估、术中控制出血和术后个体化管理是手术成功的关键。其中控制术中出血仍是肝脏外科和麻醉医生更为关注的重要话题,因此有必要寻找一种更有效、安全的方法来减少肝切除术中出血的发生。目前低中心静脉压(LCVP)技术可以有效减少术中出血降低输血需求,为手术操作者提供更清晰的手术视野,已被广泛应用于临床。然而,国内外也有研究表明在肝切除术中应用LCVP技术的相关问题仍存在争议。因此,本文总结了LCVP技术在肝切除术中应用的相关原理、具体实施方式及对患者术后重要脏器的影响等方面,为临床医师在肝切除术中合理应用此项技术提供参考。

Hepatectomy is the main treatment for benign and malignant liver diseases. At present, with persistent development of liver surgery and related disciplines, hepatectomy has become a routine procedure in most hepatobiliary and pancreatic disease centers. When surgery enters the era of laparoscopy, laparoscopic hepatectomy has gradually become the main surgical treatment for liver tumors. Accurate perioperative evaluation, intraoperative bleeding control and postoperative individualized management are the keys to successful operation. Among them, intraoperative bleeding control remain a more important topic for surgeons and anesthesiologists in liver surgery. Consequently, it is necessary to explore a more effective and safer technology to minimize intraoperative bleeding during hepatectomy. Currently, low central venous pressure (LCVP) can effectively minimize intraoperative bleeding, reduce the requirement for blood transfusion, and provide a clearer view of surgical field for surgeons, which has been widely applied in clinical practice. However, studies at home and abroad also show that the application of LCVP in hepatectomy remains controversial. Therefore, in this article, relevant principles, specific implementation patterns and the impact of LCVP on vital organs of patients after hepatectomy were reviewed, aiming to provide reference for clinicians to rationally apply LCVP in hepatectomy.

[1]
Stephanos M, Stewart CMB, Mahmood A, et al. Low versus standard central venous pressure during laparoscopic liver resection: a systematic review, meta-analysis and trial sequential analysis[J]. Ann Hepatobiliary Pancreat Surg, 2024, 28(2): 115-124. DOI: 10.14701/ahbps.23-137.
[2]
中国医师协会急诊医师分会, 中国医师协会急诊医师分会循环与血流动力学学组, 中华医学会急诊医学分会, 等. 中心静脉压急诊临床应用中国专家共识(2020)[J]. 临床急诊杂志, 2020, 21(6): 421-428. DOI: 10.13201/j.issn.1009-5918.2020.06.001.
[3]
中国医师协会外科医师分会肝脏外科医师委员会. 肝脏外科手术止血中国专家共识(2023版)[J]. 中国实用外科杂志, 2023, 43(1): 48-58. DOI:10.19538/j.cjps.issn1005-2208.2023.01.06.
[4]
Huntington JT, Royall NA, Schmidt CR. Minimizing blood loss during hepatectomy: a literature review[J]. J Surg Oncol, 2014, 109(2): 81-88. DOI: 10.1002/jso.23455.
[5]
Wang WD, Liang LJ, Huang XQ, et al. Low central venous pressure reduces blood loss in hepatectomy[J]. World J Gastroenterol, 2006, 12(6): 935-939. DOI: 10.3748/wjg.v12.i6.935.
[6]
Melendez JA, Arslan V, Fischer ME, et al. Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction[J]. J Am Coll Surg, 1998, 187(6): 620-625. DOI: 10.1016/s1072-7515(98)00240-3.
[7]
Zatloukal J, Pradl R, Kletecka J, et al. Comparison of absolute fluid restriction versus relative volume redistribution strategy in low central venous pressure anesthesia in liver resection surgery: a randomized controlled trial[J]. Minerva Anestesiol, 2017, 83(10): 1051-1060. DOI: 10.23736/S0375-9393.17.11824-9.
[8]
Liu TS, Shen QH, Zhou XY, et al. Application of controlled low central venous pressure during hepatectomy: a systematic review and meta-analysis[J]. J Clin Anesth, 2021, 75: 110467. DOI: 10.1016/j.jclinane.2021.110467.
[9]
Soonawalla ZF, Stratopoulos C, Stoneham M, et al. Role of the reverse-Trendelenberg patient position in maintaining low-CVP anaesthesia during liver resections[J]. Langenbecks Arch Surg, 2008, 393(2): 195-198. DOI: 10.1007/s00423-007-0222-1.
[10]
Sand L, Rizell M, Houltz E, et al. Effect of patient position and PEEP on hepatic, portal and central venous pressures during liver resection[J]. Acta Anaesthesiol Scand, 2011, 55(9): 1106-1112. DOI: 10.1111/j.1399-6576.2011.02502.x.
[11]
Sand L, Lundin S, Rizell M, et al. Nitroglycerine and patient position effect on central, hepatic and portal venous pressures during liver surgery[J]. Acta Anaesthesiol Scand, 2014, 58(8): 961-967. DOI: 10.1111/aas.12349.
[12]
Ukere A, Meisner S, Greiwe G, et al. The influence of PEEP and positioning on central venous pressure and venous hepatic hemodynamics in patients undergoing liver resection[J]. J Clin Monit Comput, 2017, 31(6): 1221-1228. DOI: 10.1007/s10877-016-9970-1.
[13]
王小梅, 曹琴, 成可熹, 等. 不同体位控制低中心静脉压在腹腔镜肝切除术中的应用[J]. 实用医院临床杂志, 2020, 17(3): 175-177. DOI: 10.3969/j.issn.1672-6170.2020.03.051.
[14]
Feltracco P, Brezzi ML, Barbieri S, et al. Epidural anesthesia and analgesia in liver resection and living donor hepatectomy[J]. Transplant Proc, 2008, 40(4): 1165-1168. DOI: 10.1016/j.transproceed.2008.03.108.
[15]
Koul A. Reply[J]. Liver Transpl, 2018, 24(7):975. DOI: 10.1002/lt.25050.
[16]
史惠中, 熊奇如, 夏俊, 等. 控制性低中心静脉压在原发性肝癌伴肝炎后肝硬化患者腹腔镜肝切除中的应用[J]. 中国普通外科杂志, 2020, 29(1): 27-34. DOI: 10.7659/j.issn.1005-6947.2020.01.004.
[17]
卢基成. 多巴酚丁胺联合硝酸甘油在控制性低中心静脉压下肝部分切除手术的应用[D]. 广州: 广州医科大学, 2020. DOI: 10.27043/d.cnki.ggzyc.2020.000112.
[18]
Ryu HG, Nahm FS, Sohn HM, et al. Low central venous pressure with milrinone during living donor hepatectomy[J]. Am J Transplant, 2010, 10(4): 877-882. DOI: 10.1111/j.1600-6143.2010.03051.x.
[19]
Yang P, Gao S, Chen X, et al. Milrinone is better choice for controlled low central venous pressure during hepatectomy: a randomized, controlled trial comparing with nitroglycerin[J]. Int J Surg, 2021, 94: 106080. DOI: 10.1016/j.ijsu.2021.106080.
[20]
Hasegawa K, Takayama T, Orii R, et al. Effect of hypoventilation on bleeding during hepatic resection: a randomized controlled trial[J]. Arch Surg, 2002, 137(3): 311-315. DOI: 10.1001/archsurg.137.3.311.
[21]
Iguchi T, Ikegami T, Fujiyoshi T, et al. Low positive airway pressure without positive end-expiratory pressure decreases blood loss during hepatectomy in living liver donors[J]. Dig Surg, 2017, 34(3): 192-196. DOI: 10.1159/000447755.
[22]
Kobayashi S, Honda G, Kurata M, et al. An experimental study on the relationship among airway pressure, pneumoperitoneum pressure, and central venous pressure in pure laparoscopic hepatectomy[J]. Ann Surg, 2016, 263(6): 1159-1163. DOI: 10.1097/SLA.0000000000001482.
[23]
陈骏, 刘朋, 张国华, 等. 间歇低气道压力通气联合低中心静脉压技术在腹腔镜肝切除术中的应用:前瞻性随机对照研究[J]. 中国微创外科杂志, 2021, 21(7): 595-599. DOI: 10.3969/j.issn.1009-6604.2021.07.003.
[24]
Otsubo T, Takasaki K, Yamamoto M, et al. Bleeding during hepatectomy can be reduced by clamping the inferior vena cava below the liver[J]. Surgery, 2004, 135(1): 67-73. DOI: 10.1016/s0039-6060(03)00343-x.
[25]
Rahbari NN, Koch M, Zimmermann JB, et al. Infrahepatic inferior vena cava clamping for reduction of central venous pressure and blood loss during hepatic resection: a randomized controlled trial[J]. Ann Surg, 2011, 253(6): 1102-1110. DOI: 10.1097/SLA.0b013e318214bee5.
[26]
Zhu P, Lau WY, Chen YF, et al. Randomized clinical trial comparing infrahepatic inferior vena cava clamping with low central venous pressure in complex liver resections involving the Pringle manoeuvre[J]. Br J Surg, 2012, 99(6): 781-788. DOI: 10.1002/bjs.8714.
[27]
He P, He K, Zhong F, et al. Meta-analysis of infrahepatic inferior vena cava clamping combined with the pringle maneuver during hepatectomy[J]. Asian J Surg, 2021, 44(1): 18-25. DOI: 10.1016/j.asjsur.2020.04.022.
[28]
Ueno M, Kawai M, Hayami S, et al. Partial clamping of the infrahepatic inferior vena cava for blood loss reduction during anatomic liver resection: a prospective, randomized, controlled trial[J]. Surgery, 2017, 161(6): 1502-1513. DOI: 10.1016/j.surg.2016.12.010.
[29]
商阳阳, 肖林康, 谢炜, 等. 腹腔镜肝切除术中肝下下腔静脉部分阻断对中心静脉压和出血量影响研究[J]. 中国实用外科杂志, 2021, 41(7): 795-799. DOI: 10.19538/j.cjps.issn1005-2208.2021.07.14.
[30]
Xiao LK, Huang P, Wu K, et al. Effect of infrahepatic inferior vena cava partial clamping on central venous pressure and intraoperative blood loss during laparoscopic hepatectomy[J]. Surg Endosc, 2021, 35(6): 2773-2780. DOI: 10.1007/s00464-020-07709-y.
[31]
Zhou Y, Zhang Z, Wan T. Effect of infrahepatic inferior vena cava clamping on bleeding during hepatic resection: a meta-analysis[J]. Asian J Surg, 2018, 41(6): 523-529. DOI: 10.1016/j.asjsur.2017.11.003.
[32]
《腹腔镜肝胆胰手术操作指南》制定委员会. 腹腔镜肝胆胰手术操作指南[J]. 临床肝胆病杂志, 2019, 35(7): 1450-1458. DOI: 10.3969/j.issn.1001-5256.2019.07.008.
[33]
Pan YX, Wang JC, Lu XY, et al. Intention to control low central venous pressure reduced blood loss during laparoscopic hepatectomy: a double-blind randomized clinical trial[J]. Surgery, 2020, 167(6): 933-941. DOI: 10.1016/j.surg.2020.02.004.
[34]
戴华磊, 陆小丽, 杨洪吉. 控制性低中心静脉压技术用于腹腔镜下老年肝癌切除术的效果及操作要点[J]. 中国现代普通外科进展, 2019, 22(3): 207-209. DOI: 10.3969/j.issn.1009-9905.2019.03.010.
[35]
van Wonderen SF, Peters AL, Grey S, et al. Standardized reporting of pulmonary transfusion complications: development of a model reporting form and flowchart[J]. Transfusion, 2023, 63(6): 1161-1171. DOI: 10.1111/trf.17346.
[36]
Wang B, He HK, Cheng B, et al. Effect of low central venous pressure on postoperative pulmonary complications in patients undergoing liver transplantation[J]. Surg Today, 2013, 43(7): 777-781. DOI: 10.1007/s00595-012-0419-y.
[37]
Jayaraman S, Khakhar A, Yang H, et al. The association between central venous pressure, pneumoperitoneum, and venous carbon dioxide embolism in laparoscopic hepatectomy[J]. Surg Endosc, 2009, 23(10): 2369-2373. DOI: 10.1007/s00464-009-0359-9.
[38]
王红, 郭旭. 控制性低中心静脉压技术用于腹腔镜肝叶切除术的临床研究[J]. 北京医学, 2011, 33(8): 608-611.
[39]
黄微, 黎阳, 阮林, 等. 控制性低中心静脉压对肝细胞肝癌切除术患者围手术期肝功能的影响[J]. 肿瘤预防与治疗, 2015, 28(1): 13-17. DOI: 10.3969/j.issn.1674-0904.2015.01.003.
[40]
Wu G, Chen T, Chen Z. Effect of controlled low central venous pressure technique on postoperative hepatic insufficiency in patients undergoing a major hepatic resection[J]. Am J Transl Res, 2021, 13(7): 8286-8293.
[41]
Correa-Gallego C, Berman A, Denis SC, et al. Renal function after low central venous pressure-assisted liver resection: assessment of 2116 cases[J]. HPB, 2015, 17(3): 258-264. DOI: 10.1111/hpb.12347.
[42]
Wisén E, Almazrooa A, Sand Bown L, et al. Myocardial, renal and intestinal injury in liver resection surgery-a prospective observational pilot study[J]. Acta Anaesthesiol Scand, 2021, 65(7): 886-894. DOI: 10.1111/aas.13823.
[43]
Erkoç SK, Kırımker EO, Büyük S, et al. Reducing risk for acute kidney injury after living donor hepatectomy by protocolized fluid restriction: single-center experience[J]. Transplant Proc, 2022, 54(8): 2243-2247. DOI: 10.1016/j.transproceed.2022.08.006.
[44]
查本俊, 吴志云, 熊华平, 等. 急性等容血液稀释联合低中心静脉压对肝癌手术脑氧代谢的影响[J]. 临床麻醉学杂志, 2013, 29(5): 454-457.
[45]
Guo JR, Shen HC, Liu Y, et al. Effect of acute normovolemic hemodilution combined with controlled low central venous pressure on cerebral oxygen metabolism of patients with hepalobectomy[J]. Hepatogastroenterology, 2014, 61(136): 2321-2325.
[46]
吕华燕, 胡崇辉, 蓝志坚. 控制性低中心静脉压技术对腹腔镜肝切除术患者脑氧饱和度的影响[J]. 中国内镜杂志, 2022, 28(4): 49-54. DOI: 10.12235/E20210437.
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