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中华肝脏外科手术学电子杂志 ›› 2026, Vol. 15 ›› Issue (03) : 433 -438. doi: 10.3877/cma.j.issn.2095-3232.2026.03.020

综述

循环肿瘤DNA在胰腺癌早期诊断中的研究进展
杜飞, 郑希彦, 陈贤清, 李瑞曦, 张广权, 史宪杰()   
  1. 518000 深圳,中山大学附属第八医院肝胆胰外科
  • 收稿日期:2025-10-12 出版日期:2026-06-10
  • 通信作者: 史宪杰
  • 基金资助:
    广东省基础与应用基础研究基金企业联合基金(2023A1515220186)

Research progress in circulating tumor DNA in early diagnosis of pancreatic cancer

Fei Du, Xiyan Zheng, Xianqing Chen, Ruixi Li, Guangquan Zhang, Xianjie Shi()   

  1. Department of Hepatobiliary and Pancreatic Surgery, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, China
  • Received:2025-10-12 Published:2026-06-10
  • Corresponding author: Xianjie Shi
引用本文:

杜飞, 郑希彦, 陈贤清, 李瑞曦, 张广权, 史宪杰. 循环肿瘤DNA在胰腺癌早期诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(03): 433-438.

Fei Du, Xiyan Zheng, Xianqing Chen, Ruixi Li, Guangquan Zhang, Xianjie Shi. Research progress in circulating tumor DNA in early diagnosis of pancreatic cancer[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2026, 15(03): 433-438.

胰腺癌是一种高度侵袭性的恶性肿瘤,发病率持续攀升。大多数病例发现时已处于晚期,伴有无法切除的局部晚期或转移性疾病,即使在接受根治性切除术的个体中,复发也较为普遍。对于高危人群,尚无普遍接受的筛查方式,诊断、治疗评估和复发检测主要依赖于影像学检查。迫切需要有效的方法帮助诊断、疗效评估以及检测复发。随着循环肿瘤DNA(ctDNA)、循环肿瘤细胞和外泌体等液体活检新兴技术逐渐成熟及应用,在胰腺癌的研究中具有潜在优势。本文就ctDNA在胰腺癌的早期诊断中的研究进展作一综述。

Pancreatic cancer is a highly-invasive malignancy, with an increasing incidence rate. Upon admission, most cases are diagnosed with advanced stage, complicated with unresectable locally advanced or metastatic diseases. Recurrence is commonly seen even in individuals undergoing radical resection. For high-risk groups, there is no widely-accepted screening method. Diagnosis, treatment evaluation and recurrence detection mainly depend on imaging examination. Effective methods are urgently required to assist diagnosis, efficacy evaluation and recurrence detection. Emerging technologies such as circulating tumor DNA (ctDNA), circulating tumor cells and exosomes have gradually matured and applied, which showcase potential advantages in the study of pancreatic cancer. In this article, research progress in the application of ctDNA in the early diagnosis of pancreatic cancer was reviewed.

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