NLRP3 inflammasome and its mechanism in liver ischemia-reperfusion injury

doi:10.3877/cma.j.issn.2095-3232.2024.03.024

Abstract

Abstract:

Liver ischemia-reperfusion injury (IRI) refers to the restoration of oxygenated blood flow to the liver after a period of liver ischemia, which exacerbates liver injury. Inflammatory reaction is one of the main causes of liver IRI, and inflammatory reaction mediated by NLRP3 inflammasome receptor is dominant. Studies have shown that IRI can be alleviated by inhibiting the activation of inflammasomes. In this article, the latest progress in NLRP3-mediated activation and regulation of inflammasomes, and its mechanism in liver IRI were reviewed.

Key words: NLRP3, Inflammasome, Liver, Ischemical-reperfusion injury

Yunfei Zhang, Tuxun Tuerhongjiang·. NLRP3 inflammasome and its mechanism in liver ischemia-reperfusion injury[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(03): 398-403.

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