Liver ischemia-reperfusion injury and cGAS-STING signaling pathway

doi:10.3877/cma.j.issn.2095-3232.2024.03.023

Abstract

Abstract:

Liver ischemia-reperfusion injury (IRI) mainly occurs in liver surgery (liver transplantation, hepatectomy) and multiple circulatory shock events, which is an inevitable clinical problem for postoperative liver dysfunction, disease outcome and poor prognosis of patients, etc. As a newly-discovered key DNA receptor in recent years, cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor. When intracellular DNA damage occurs, cGAS-STING signaling pathway will be activated and relevant immune cytokines will be generated, which will induce inflammatory immune activation and aggravate inflammatory hepatocyte damage. In this article, the activation process of cGAS-STING signaling pathway and its role and mechanism in liver IRI were reviewed.

Key words: Ischemia-reperfusion injury, Signal pathway, cGAS-STING signaling pathway, Cell factor

Tuersunmaimaiti Abudusalamu·, Tuxun Tuerhongjiang·, Hao Wen. Liver ischemia-reperfusion injury and cGAS-STING signaling pathway[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(03): 394-397.

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URL: https://zhgzwkssxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3232.2024.03.023

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