Analysis on infection and drug resistance of Acinetobacter baumannii

doi:10.3877/cma.j.issn.2095-3232.2016.05.012

Abstract

Abstract:

Objective

To investigate the infection and drug resistance of Acinetobacter baumannii in the Third Affiliated Hospital of Sun Yat-sen University.

Methods

Clinical data of 209 patients infected with Acinetobacter baumannii in the Third Affiliated Hospital of Sun Yat-sen University between June 2012 and December 2014 were retrospectively analyzed. Among the patients, 160 were males and 49 were females with the average age of (55±18) years old. The informed consents of all patients were obtained and the local ethical committee approval was received. The specimen source, ward distribution and drug resistance of Acinetobacter baumannii were observed. The comparison of drug resistance was conducted using Chi-square test and Bonferroni test.

Results

Two hundred and thirty-six strains of Acinetobacter baumannii were isolated in the hospital, and most were isolated from Department of Liver Transplantation (50 strains, 21.2%), the next were Department of Rehabilitation (34 strains, 14.4%) and Surgical Intensive Care Unit (SICU) (21 strains, 8.9%). Sputum specimens were the main source of Acinetobacter baumannii, respectively accouting for 84%, 76% and 71% in the three wards, where Acinetobacter baumannii had high drug resistance to the common antibiotics used in clinical. The drug resistance rate to sulfamethoxazole of Acinetobacter baumannii in Department of Liver Transplantation was 76%, significantly higher than 33% of SICU (χ²=11.60, P<0.017).

Conclusions

Acinetobacter baumannii is found most in Department of Liver Transplantation, which is followed by Department of Rehabilitation and SICU. Sputum specimen is the main source of Acinetobacter baumannii. Acinetobacter baumannii detected in the three wards has a high drug resistance to common antibiotics.

Key words: Acinetobacter baumannii, Infection, Multidrug resistance-associated proteins, Liver transplantation

Jianrong Liu, Haijin Lyu, Yuling An, Xiaomeng Yi, Xuxia Wei, Liang Xiong, Lijuan Li, Yingcai Zhang, Yang Yang, Huimin Yi. Analysis on infection and drug resistance of Acinetobacter baumannii[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2016, 05(05): 319-322.

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References 20

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科室	菌株（株）	构成比（%）
肝移植科	50	21.2
康复科	34	14.4
外科ICU	21	8.9
神经外科	18	7.6
神经内科	17	7.2
感染科	16	6.8
内科ICU	14	5.9
心内科	12	5.1
普外科	12	5.1
儿科	8	3.4
胸外科	7	3.0
其他	27	11.4
合计	236	100.0

科室	菌株（株）	构成比（%）
肝移植科	50	21.2
康复科	34	14.4
外科ICU	21	8.9
神经外科	18	7.6
神经内科	17	7.2
感染科	16	6.8
内科ICU	14	5.9
心内科	12	5.1
普外科	12	5.1
儿科	8	3.4
胸外科	7	3.0
其他	27	11.4
合计	236	100.0

科室	例数	痰	尿	血	胆汁	腹腔积液	胸腔积液	伤口分泌物
肝移植科	50	42	1	3	1	3	0	0
康复科	34	26	7	0	0	0	0	1
外科ICU	21	15	1	2	0	1	1	1

科室	例数	痰	尿	血	胆汁	腹腔积液	胸腔积液	伤口分泌物
肝移植科	50	42	1	3	1	3	0	0
康复科	34	26	7	0	0	0	0	1
外科ICU	21	15	1	2	0	1	1	1

科室	例数	哌拉西林钠		头孢噻肟钠		头孢他啶		头孢曲松钠		头孢吡肟		替卡西林钠-克拉维酸钾		环丙沙星
科室	例数	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)
肝移植科	50	41	82	40	80	40	80	40	80	40	80	40	80	40	80
康复科	34	27	79	26	76	26	76	26	76	25	74	27	79	27	79
外科ICU	21	18	86	18	86	18	86	18	86	18	86	18	86	18	86
χ²值	?	0.35		0.69		0.69		0.69		1.22		0.39		0.39
P值	?	0.840		0.710		0.710		0.710		0.544		0.820		0.820
科室	例数	左氧氟沙星		妥布霉素		庆大霉素		阿米卡星		磺胺甲噁唑		美罗培南		四环素
科室	例数	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)	例数	耐药率(%)
肝移植科	50	39	78	39	78	41	82	39	78	38	76	40	80	39	78
康复科	34	26	76	27	79	26	76	25	74	21	62	24	71	30	88
外科ICU	21	17	81	18	86	18	86	18	86	7	33	18	86	18	86
χ²值	?	0.15		0.56		0.79		1.13		11.56		1.94		1.64
P值	?	0.930		0.760		0.680		0.570		0.003		0.380		0.440

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