In recent years, with the emergence of molecular targeting and immunotherapy, more and more patients with middle-advanced hepatocellular carcinoma (HCC) obtain benefits from translational therapy and achieve the opportunity of surgical treatment. At present, the evaluation and selection of eligible population, the formulation of the optimal translational strategy, surgical pattern and timing, precise preoperative planning and the research and development of intraoperative real-time navigation technology have become the hot spots in clinical research of HCC translational therapy. Among them, three-dimensional visualization technology is an important approach for digital medicine-assisted surgical treatment of solid tumors in recent years, which is also the core tool to realize precise planning and navigation in anatomical liver resection. Three-dimensional visualization technology utilizes three-dimensional evaluation, relies on the concept of full-course management of HCC translational treatment, precisely reflects therapeutic effect and guides treatment decision. In addition, it dynamically monitors the anatomical changes of the target liver after translational therapy, thereby formulating the optimal surgical approach. Digital medical technologies, represented by three-dimensional visualization technology, are expected to provide reliable prediction for systemic therapeutic effect by integrating novel imaging technological algorithms. In this article, the application of these technologies in the decision-making of HCC translational therapy was reviewed, and clinical practical significance was illustrated.