肝移植受者术后性功能调查及其影响因素分析

doi:10.3877/cma.j.issn.2095-3232.2014.05.005

中华肝脏外科手术学电子杂志 ›› 2014, Vol. 03 ›› Issue (05) : 279 -282. doi: 10.3877/cma.j.issn.2095-3232.2014.05.005

所属专题：文献；

临床研究

肝移植受者术后性功能调查及其影响因素分析

易小猛¹, 安玉玲¹, 吕海金¹, 魏绪霞¹, 熊亮¹, 刘剑戎¹, 易慧敏¹^,^†(

), 陈规划¹

^1. 510630　广州，中山大学附属第三医院肝移植中心　中山大学器官移植研究所　广东省器官移植中心

收稿日期:2014-08-07 出版日期:2014-10-10
通信作者: 易慧敏
基金资助:
国家重点基础研究发展计划（973计划）课题(2009CB522404); 国家十一五科技重大专项课题(2008ZX10002-026); 广州市科技计划项目(2009Z1-211)

Investigation on sexual function of recipients after liver transplantation and impact factors analysis

Xiaomeng Yi¹, Yuling An¹, Haijin Lyu¹, Xuxia Wei¹, Liang Xiong¹, Jianrong Liu¹, Huimin Yi¹^,^†(), Guihua Chen¹

^1. Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute of Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou 510630, China

Received:2014-08-07 Published:2014-10-10
Corresponding author: Huimin Yi
About author:
Corresponding author: Yi Huimin, Email: ylhmin@hotmail.com

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引用本文：

易小猛, 安玉玲, 吕海金, 魏绪霞, 熊亮, 刘剑戎, 易慧敏, 陈规划. 肝移植受者术后性功能调查及其影响因素分析[J/OL]. 中华肝脏外科手术学电子杂志, 2014, 03(05): 279-282.

Xiaomeng Yi, Yuling An, Haijin Lyu, Xuxia Wei, Liang Xiong, Jianrong Liu, Huimin Yi, Guihua Chen. Investigation on sexual function of recipients after liver transplantation and impact factors analysis[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2014, 03(05): 279-282.

目的

探讨肝移植受者术后性功能状况及其影响因素。

方法

回顾性研究2007年7月至2012年7月在中山大学附属第三医院肝移植中心接受肝移植的69例受者临床资料。所有受者均签署由医院伦理委员会批准的知情同意书，符合医学伦理学规定。受者均为男性；年龄30～55岁，中位年龄43岁；患病前性功能均正常。采用自制"肝移植受者性生活状况问卷调查表"和直接询问相结合的方式对受者进行调查。根据肝移植术后有否发生性功能障碍将受者分为性功能障碍组（23例）和性功能正常组（46例）。分析受者性功能障碍与临床参数的关系。两组率的比较采用χ²检验。

结果

69例肝移植受者术后性功能障碍发生率为33%（23/69），明显低于术前的88%（61/69）（χ²=7.56，P<0.05）。原发病为慢性重型肝炎及肝硬化（失代偿期）的受者术后性功能障碍发生率为49%（17/35），明显高于肝硬化（代偿期）及肝脏炎性肉芽肿受者的18%（6/24）（χ²=4.52，P<0.05）；认为性生活会对移植肝产生不良影响的受者术后性功能障碍发生率为83%（20/24），亦明显高于认为无影响的受者的7%（3/45）（χ²=11.63，P<0.05）。

结论

肝移植受者术后性功能较术前明显改善，性功能障碍的发生与原发病及受者对性生活的认知密切相关。

关键词: 肝移植, 性功能, 认知, 手术后医护

Objective

To investigate the sexual function and its impact factors in recipients after liver transplantation (LT).

Methods

Clinical data of 69 recipients undergoing LT in Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University from June 2007 to July 2012 were analyzed retrospectively. The informed consents of all recipients were obtained and the ethical committee approval was received. All the recipients were male with age ranging from 30 to 55 years old and a median of 43 years old. The sexual function was normal in all patients before being diseased. The recipients were surveyed using self-designed questionnaire on sexual life quality of liver transplant recipients and direct inquiry. The recipients were divided into sexual dysfunction group (n=23) and intact sexual function group (n=46). The correlation between sexual dysfunction and clinical indexes of the recipients was analyzed. The ratio of two groups was compared by Chi-square test.

Results

The incidence of sexual dysfunction of liver transplant recipients after operation was 33% (23/69), which was significantly lower than that before operation [88% (61/69) ] (χ²=7.56, P<0.05). The incidence of sexual dysfunction after operation in recipients with chronic severe hepatitis and decompensated liver cirrhosis [49% (17/35)] was significantly higher than those with compensated liver cirrhosis and liver inflammatory granuloma [18% (6/34)] (χ²=4.52, P<0.05). The incidence of sexual dysfunction was significantly higher in recipients who considered that sexual life causing adverse impacts on the liver graft [83% (20/24)], compared with those who considered that sexual life causing no impacts on the liver graft [7% (3/45) (χ²=11.63, P<0.05)].

Conclusions

The sexual function of the recipients after LT improved significantly, compared with that before LT. The incidence of sexual function is closely related with the primary diseases and the cognition on sexual life of the recipients.

Key words: Liver transplantation, Sexual fuction, Cognition, Postoperative care

表1 肝移植受者术后性功能障碍与临床参数的关系（例）

组别	例数	年龄（岁）		原发病		MELD评分（分）		术后并发症		对性生活的认知
组别	例数	<45	≥45	慢性重型肝炎及肝硬化（失代偿期）	肝硬化（代偿期）及肝脏炎性肉芽肿	<30	≥30	无	有	认为对移植肝无影响	认为对移植肝有影响
性功能障碍组	23	12	11	17	6	19	4	12	11	3	20
性功能正常组	46	21	25	18	28	39	7	27	19	42	4
χ²值	?	1.89		4.52		2.43		2.56		11.63
P值	?	>0.05		<0.05		>0.05		>0.05		<0.05

表1 肝移植受者术后性功能障碍与临床参数的关系（例）

组别	例数	年龄（岁）		原发病		MELD评分（分）		术后并发症		对性生活的认知
组别	例数	<45	≥45	慢性重型肝炎及肝硬化（失代偿期）	肝硬化（代偿期）及肝脏炎性肉芽肿	<30	≥30	无	有	认为对移植肝无影响	认为对移植肝有影响
性功能障碍组	23	12	11	17	6	19	4	12	11	3	20
性功能正常组	46	21	25	18	28	39	7	27	19	42	4
χ²值	?	1.89		4.52		2.43		2.56		11.63
P值	?	>0.05		<0.05		>0.05		>0.05		<0.05

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