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中华肝脏外科手术学电子杂志 ›› 2015, Vol. 04 ›› Issue (04) : 250 -253. doi: 10.3877/cma.j.issn.2095-3232.2015.04.014

所属专题: 文献

基础研究

c-Jun蛋白在肝细胞癌中的表达及其意义
杨跃武1, 叶志强2, 孔庆磊2, 罗刚健3,()   
  1. 1. 510630 广州,中山大学附属第三医院中医科
    2. 510630 广州,中山大学附属第三医院急诊科
    3. 510630 广州,中山大学附属第三医院麻醉科
  • 收稿日期:2015-06-12 出版日期:2015-08-10
  • 通信作者: 罗刚健
  • 基金资助:
    广东省科技计划项目(2011B61300011)

Expression of c-Jun in hepatocellular carcinoma and its significance

Yuewu Yang1, Zhiqiang Ye2, Qinglei Kong2, Gangjian Luo3,()   

  1. 1. Department of Traditional Chinese Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
    2. Department of Emergency, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
    3. Deparment of Anesthesiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
  • Received:2015-06-12 Published:2015-08-10
  • Corresponding author: Gangjian Luo
  • About author:
    Corresponding author: Luo Gangjian, Email:
引用本文:

杨跃武, 叶志强, 孔庆磊, 罗刚健. c-Jun蛋白在肝细胞癌中的表达及其意义[J]. 中华肝脏外科手术学电子杂志, 2015, 04(04): 250-253.

Yuewu Yang, Zhiqiang Ye, Qinglei Kong, Gangjian Luo. Expression of c-Jun in hepatocellular carcinoma and its significance[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2015, 04(04): 250-253.

目的

探讨c-Jun蛋白在肝细胞癌(肝癌)中的表达及其与预后的关系。

方法

回顾性分析2010年1月至2013年12月在中山大学附属第三医院行肝切除术的137例肝癌患者临床资料。其中男112例,女25例;年龄26~73岁,中位年龄45岁。所有患者均签署知情同意书,符合医学伦理学规定。采用免疫组化法检测肝癌组织c-Jun蛋白表达。根据免疫组化法染色评分将患者分为高表达组(75例)和低表达组(62例)。分析两组患者临床病理学参数及c-Jun蛋白表达与生存预后的关系。两组患者临床病理学参数比较采用χ2检验,生存分析采用Kaplan-Meier法和Log-rank检验。

结果

肝癌c-Jun蛋白表达与患者HBsAg、AFP、肿瘤直径、肿瘤包膜、肿瘤血管侵犯有关(χ2=5.27,32.68,4.86,1.04,4.62;P<0.05)。高表达组患者3、5年累积生存率分别为64.14%、41.20%,低表达组相应为72.04%、61.21%,高表达组患者的总体生存率明显低于低表达组(χ2=5.19,P<0.05)。

结论

c-Jun蛋白可能在肝癌的发生、发展中起到重要作用,其高表达预示患者预后不良。

Objective

To investigate the expression of c-Jun in hepatocellular carcinoma (HCC) and its correlation with prognosis.

Methods

Clinical data of 137 patients with HCC undergoing hepatectomy in the Third Affiliated Hospital of Sun Yat-sen University between Janunary 2010 and December 2013 were retrospectively studied. Among the 137 patients, 112 were males and 25 were females with the age ranging from 26 to 73 years old and the median of 45 years old. The informed consents of all patients were obtained and the local ethical committee approval had been received. The expression of c-Jun in HCC tissues was detected by immunohistochemistry. The patients were divided into the high-expression group (n=75) and low-expression group (n=62) according to the scores of immunohistochemical staining. The clinicopathological parameters and the correlation between c-Jun expression and prognosis of the two groups were analyzed. Comparison on clinicopathological parameters was conducted using Chi-square test and survival analysis was conducted using Kaplan-Meier and Log-rank test.

Results

The expression of c-Jun in HCC was correlated with HBsAg, alpha-fetoprotein (AFP), tumor size, tumor capsule and tumor vascular invasion (χ2=5.27, 32.68, 4.86, 1.04, 4.62; P<0.05). The 3-, 5-year cumulative survival rate of the high-expression group was respectively 64.14% and 41.20% and those of the low-expression group was respectively 72.04% and 61.21%. The overall survival of the high-expression group was significantly lower than that of the low-expression group (χ2=5.19, P<0.05).

Conclusion

c-Jun may play an important role in the occurrence and development of HCC and high expression of c-Jun indicates poor prognosis.

表1 肝癌组织c-Jun的表达与临床病理学参数的关系(例)
[1]
Kang TW, Lim HK, Lee MW, et al. Perivascular versus nonperivascular small HCC treated with percutaneous RF ablation: retrospective comparison of long-term therapeutic outcomes[J]. Radiology, 2014, 270(3): 888-899.
[2]
范上达,邱宗祥,潘冬平.肝癌的综合治疗[J].中华消化外科杂志, 2011, 10(4): 241-246.
[3]
Daniele A, Divella R, Quaranta M, et al. Clinical and prognostic role of circulating MMP-2 and its inhibitor TIMP-2 in HCC patients prior to and after trans-hepatic arterial chemo-embolization[J]. Clin Biochem, 2014, 47(3): 184-190.
[4]
Finkelmeier F, Bettinger D, Köberle V, et al. Single measurement of hemoglobin predicts outcome of HCC patients[J]. Med Oncol, 2014, 31(1): 806.
[5]
郭宇,陈规划.肝细胞肝癌合并肝静脉、下腔静脉及右心房癌栓的诊断与治疗[J/CD].中华肝脏外科手术学电子杂志,2013,2(1): 53-55.
[6]
安玉玲,张婷婷,蔡常洁.西罗莫司用于治疗肝癌肝移植术后肿瘤复发患者的疗效分析[J].器官移植,2011, 2(2): 73-76.
[7]
Kim S, Lee J, Lee SK, et al. Protein kinase C-αdownregulates estrogen receptor-αby suppressing c-Jun phosphorylation in estrogen receptor-positive breast cancer cells[J]. Oncol Rep, 2014, 31(3): 1423-1428.
[8]
Yang Z, Zhang Y, Wang L. A feedback inhibition between miRNA-127 and TGFbeta/c-Jun cascade in HCC cell migration via MMP13[J]. PLoS One, 2013, 8(6):e65256.
[9]
Rana A, Rana B, Mishra R, et al. Mixed lineage Kinase-c-Jun N-Terminal kinase axis: a potential therapeutic target in cancer[J]. Genes Cancer, 2013, 4(9/10): 334-341.
[10]
Tinzl M, Chen B, Chen SY, et al. Interaction between c-jun and androgen receptor determines the outcome of taxane therapy in castration resistant prostate cancer[J]. PLoS One, 2013, 8(11): e79573.
[11]
Shao J, Teng Y, Padia R, et al. COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis[J]. Neoplasia, 2013, 15(9): 1075-1085.
[12]
Eckhoff K, Flurschütz R, Trillsch F, et al. The prognostic significance of Jun transcription factors in ovarian cancer[J]. J Cancer Res Clin Oncol, 2013, 139(10): 1673-1680.
[13]
Li Z, Zhu Y, Yu M, et al. c-Jun is involved in interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human bladder cancer T24 cells[J]. Urol Oncol, 2013, 31(2): 228-233.
[14]
Yuan F, Xu Z, Yang M, et al. Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer[J]. PLoS One, 2013, 8(7): e69317.
[15]
Guo H, Xu YM, Ye ZQ, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IκBα, c-Jun and androgen receptor[J]. Pharmazie, 2013, 68(6): 431-434.
[16]
Gonzalez-Villasana V, Gutiérrez-Puente Y, Tari AM. Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells[J]. Oncol Rep, 2013, 30(3): 1506-1510.
[17]
Zhang H, Yu C, Dai J, et al. Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of beta-catenin activation of the DKK1 promoter in prostate cancer[J]. Oncogene, 2014, 33(19): 2464-2477.
[18]
Cao Z, Zhang R, Li J, et al. X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis[J]. J Biol Chem, 2013, 288(28): 20238-20247.
[19]
Hu L, Xia L, Zhou H, et al. TF/FVⅡa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620[J]. Tumour Biol, 2013, 34(5): 2573-2581.
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