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中华肝脏外科手术学电子杂志

中华肝脏外科手术学电子杂志 ›› 2015, Vol. 04 ›› Issue (06) : 368 -371. doi: 10.3877/cma.j.issn.2095-3232.2015.06.011

所属专题： 文献；

临床研究

肝移植治疗淋巴瘤合并慢性乙型病毒性肝炎化疗后急性肝衰竭三例分析
唐晖1, 傅斌生1, 汪国营1, 易述红1, 姜楠1, 张英才1, 姚嘉1, 杨扬1, 易慧敏1,†(), 陈规划1   
  1. 1. 510630　广州，中山大学附属第三医院肝移植中心
  • 收稿日期:2015-08-24 出版日期:2015-12-10
  • 通信作者: 易慧敏
  • 基金资助:
    国家自然科学基金(81370575，81372243，81172036); 十二五科技重大专项(2012ZX10002016-023，2012ZX10002017-005); 广州市科技计划项目(201400000001-3，2014J4100183)

Liver transplantation for acute liver failure in 3 patients with lymphoma complicated with chronic hepatitis B after chemotherapy

Hui Tang1, Binsheng Fu1, Guoying Wang1, Shuhong Yi1, Nan Jiang1, Yingcai Zhang1, Jia Yao1, Yang Yang1, Huimin Yi1,†(), Guihua Chen1   

  1. 1. Organ Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
  • Received:2015-08-24 Published:2015-12-10
  • Corresponding author: Huimin Yi
  • About author:
    Corresponding author: Yi Huimin, Email:
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唐晖, 傅斌生, 汪国营, 易述红, 姜楠, 张英才, 姚嘉, 杨扬, 易慧敏, 陈规划. 肝移植治疗淋巴瘤合并慢性乙型病毒性肝炎化疗后急性肝衰竭三例分析[J]. 中华肝脏外科手术学电子杂志, 2015, 04(06): 368-371.

Hui Tang, Binsheng Fu, Guoying Wang, Shuhong Yi, Nan Jiang, Yingcai Zhang, Jia Yao, Yang Yang, Huimin Yi, Guihua Chen. Liver transplantation for acute liver failure in 3 patients with lymphoma complicated with chronic hepatitis B after chemotherapy[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2015, 04(06): 368-371.

目的

探讨肝移植治疗淋巴瘤合并慢性乙型病毒性肝炎（慢乙肝）化疗后急性肝衰竭的疗效。

方法

回顾性分析2009年3月至2014年7月在中山大学附属第三医院接受肝移植的3例淋巴瘤合并慢乙肝化疗后急性肝衰竭患者临床资料。所有患者均签署知情同意书，符合医学伦理学规定。3例患者术前诊断为淋巴瘤合并慢乙肝，多次化疗后出现乙型病毒性肝炎（乙肝）重新活动，导致急性肝衰竭。分析3例患者术中、术后免疫抑制方案和抗病毒治疗情况，观察术后淋巴瘤和乙肝复发情况及生存预后。

结果

3例患者均急诊行肝移植治疗。患者术后早期免疫抑制方案为他克莫司（FK506）+肾上腺皮质激素（激素），术后3个月及早停用激素，改FK506单药免疫抑制治疗。术后加强抗乙型肝炎病毒治疗，抗病毒方案为恩替卡韦联合乙肝免疫球蛋白。随访至投稿日期，1例患者术后1个月余死于胆道狭窄、感染性休克；余2例恢复良好，未见淋巴瘤和乙肝复发。

结论

淋巴瘤合并慢乙肝化疗后急性肝衰竭患者行肝移植治疗，术后早期停用激素，加强抗病毒治疗，定期随访，可获得良好的治疗效果。

关键词: 肝移植, 淋巴瘤, 肝炎病毒，乙型, 肝功能衰竭，急性
Objective

To investigate the curative effect of liver transplantation (LT) for acute liver failure in patients with lymphoma complicated with chronic hepatitis B (CHB) after chemotherapy.

Methods

Clinical data of 3 patients with lymphoma complicated with CHB and acute liver failure after chemotherapy undergoing LT in the Third Affiliated Hospital of Sun Yat-sen University between March 2009 and July 2014 were retrospectively studied. The informed consents of all patients were obtained and the local ethical committee approval had been received. The 3 patients were diagnosed as lymphoma complicated with CHB before operation. Hepatitis B virus (HBV) reactivated after multiple chemotherapies and caused acute liver failure. The intraoperative and postoperative immunosuppressive regimens and antiviral therapy of the patients were analyzed. The recurrence of lymphoma and HBV and survival prognosis after operation were observed.

Results

The 3 patients underwent emergency LT. The early postoperative immunosuppressive regimen was tacrolimus (FK506) + adrenocortical hormone (hormone). FK506 monotherapy was used when hormone was stopped in 3 months after LT. Anti-HBV treatment was strengthened after LT with the regimen of entecavir combined with hepatitis B immune globulin. The patients were followed up till the date of submission. One patient died of biliary stricture and septic shock 1 month after LT and the other 2 patients recovered well without recurrence of lymphoma and hepatitis B.

Conclusions

Patients with lymphoma complicated with CHB and acute liver failure after chemotherapy can achieve favorable curative effect by LT, on condition that hormone is withdrawn early after operation, antivirus treatment is strengthened and regular follow-up is given.

Key words: Liver transplantation, Lymphoma, Hepatitis B virus, Liver failure, acute
[1]
Seetharam A, Perrillo R, Gish R. Immunosuppression in patients with chronic hepatitis B[J]. Curr Hepatol Rep, 2014(13): 235-244.
[2]
Torres HA, Davila M. Reactivation of hepatitis B virus and hepatitis C virus in patients with cancer[J]. Nat Rev Clin Oncol, 2012, 9(3):156-166.
[3]
Kim E, Yune S, Ha JM, et al. Hepatitis B virus reactivation during anti-cancer chemotherapy in patients with past hepatitis B virus infection[J]. Hepatogastroenterology, 2014, 61(134):1704-1711.
[4]
Josting A, Wolf J, Diehl V. Hodgkin disease: prognostic factors and treatment strategies[J]. Curr Opin Oncol, 2000, 12(5):403-411.
[5]
Sperl J, Frankova S, Kieslichova E, et al. Urgent liver transplantation for chemotherapy-induced HBV reactivation: a suitable option in patients recently treated for malignant lymphoma[J]. Transplant Proc, 2013, 45(7):2834-2837.
[6]
牛建花，杨华，张琪，等．HBsAg阳性弥漫大B细胞淋巴瘤化放疗后HBV再激活伴肝衰竭肝移植疗效个例报告[J]．中国实验血液学杂志，2014, 22(4):1005-1011.
[7]
易述红，易慧敏，傅斌生，等．肝移植术后新发恶性肿瘤的发生和防治(附九例报告)[J/CD]．中华肝脏外科手术学电子杂志，2014, 3(3):148-151.
[8]
杨扬，张英才．肝移植术后免疫抑制剂撤退的研究进展[J]．器官移植，2013, 4(6): 320-324.
[9]
Kusumoto S, Tanaka Y, Suzuki R, et al. Monitoring of hepatitis B virus (HBV) DNA and risk of HBV reactivation in B-cell lymphoma: a prospective observational study[J]. Clin Infect Dis, 2015, DOI: 10.1093/cid/civ344[Epub ahead of print].
[10]
Shouval D, Shibolet O. Immunosuppression and HBV reactivation[J]. Semin Liver Dis, 2013, 33(2):167-177.
[11]
Borde JP, Kern WV, Becker J, et al. Hepatitis B reactivation following immunosuppressive therapy and screening adherence: a neglected problem?[J]. Dtsch Med Wochenschr, 2012, 137(28/29):1458-1462.
[12]
Kim JM, Kwon CH, Joh JW, et al. Liver transplantation in lymphoma patients with hepatitis B virus reactivation[J]. Transplant Proc, 2013, 45(8):2988-2991.
[13]
Kusumoto S, Tanaka Y, Mizokami M, et al. Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma[J]. Int J Hematol, 2009, 90(1):13-23.
[14]
Kinch A, Cavelier L, Bengtsson M, et al. Donor or recipient origin of posttransplant lymphoproliferative disorders following solid organ transplantation[J]. Am J Transplant, 2014, 14(12):2838-2845.
[15]
Dutkowski P, Linecker M, DeOliveira ML, et al. Challenges to liver transplantation and strategies to improve outcomes[J]. Gastroenterology, 2015, 148(2):307-323.
[16]
Mancuso A, Mazzola A, Cabibbo G, et al. Survival of patients treated with sorafenib for hepatocellular carcinoma recurrence after liver transplantation: a systematic review and meta-analysis[J]. Dig Liver Dis, 2015, 47(4):324-330.
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