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中华肝脏外科手术学电子杂志 ›› 2017, Vol. 06 ›› Issue (02) : 113 -117. doi: 10.3877/cma.j.issn.2095-3232.2017.02.010

所属专题: 经典病例 文献

临床研究

冠腔分流术治疗门静脉高压症上消化道出血——40年国内报道病例分析
曲凯1, 刘昌1,()   
  1. 1. 710061 西安交通大学第一附属医院肝胆外科
  • 收稿日期:2016-12-28 出版日期:2017-04-10
  • 通信作者: 刘昌
  • 基金资助:
    国家自然科学基金(81201549,81272644,81472247); 陕西省重点科技创新团队项目(2013KCJ-23); 西安交通大学第一附属医院临床研究课题(XJTU1AF-CRF-2015-003,XJTU1AF-CRF-2015-011)

Coronary-caval shunt for upper gastrointestinal bleeding caused by portal hypertension: analysis of domestic case report over 40 years

Kai Qu1, Chang Liu1,()   

  1. 1. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710061, China
  • Received:2016-12-28 Published:2017-04-10
  • Corresponding author: Chang Liu
  • About author:
    Corresponding author: Liu Chang, Email:
引用本文:

曲凯, 刘昌. 冠腔分流术治疗门静脉高压症上消化道出血——40年国内报道病例分析[J/OL]. 中华肝脏外科手术学电子杂志, 2017, 06(02): 113-117.

Kai Qu, Chang Liu. Coronary-caval shunt for upper gastrointestinal bleeding caused by portal hypertension: analysis of domestic case report over 40 years[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2017, 06(02): 113-117.

目的

探讨冠腔分流术在治疗门静脉高压症上消化道出血中的临床疗效。

方法

计算机检索1976年1月至2016年11月中国知网、万方数据、维普网、中国生物医学文献数据库的全部公开发表的冠腔分流术相关中文文献。中文检索词:冠腔分流、冠状静脉-腔静脉分流、胃冠状静脉-下腔静脉分流、胃冠状静脉-腔静脉分流。对文献进行数据提取,分析患者临床特征、手术指标及临床预后。患者术前与术后数据的比较采用t检验。

结果

共检索到冠腔分流术相关文献8篇,纳入患者60例。其中男44例,女16例;年龄19~62岁,中位年龄43岁。80%(48/60)患者存在上消化道出血史。术前肝功能Child-Pugh分级A级27例,B级29例,4例无分级。88%(53/60)患者使用搭桥血管进行胃冠状静脉与下腔静脉吻合,12%(7/60)患者术中未使用搭桥血管。在搭桥血管选择方面,使用脾静脉31例,大隐静脉7例,颈内静脉4例,颈外静脉4例,人工血管4例,精索内静脉2例,胃网膜右静脉1例。行冠腔分流术后患者门静脉压力降低的中位数为3.0(1.4~7.2)cmH2O(1 cmH2O=0.098 kPa),胃冠状静脉降低13.0(11.0~14.0)cmH2O。纳入患者中59例获得随访,随访时间65.4 (0.3~228.0)个月。术后出现上消化道再出血5例,肝性脑病1例,未发现有腹腔积液、肝衰竭、搭桥静脉血栓等并发症。

结论

冠腔分流术的区域性降压效果显著,具有较低的消化道再出血和肝性脑病发生率,对于反复上消化道出血患者具有较好的临床疗效。

Objective

To investigate the clinical efficacy of coronary-caval shunt for upper gastrointestinal bleeding caused by portal hypertension.

Methods

Relevant literatures of coronary-caval shunt in Chinese published between January 1976 and November 2016 were searched from CNKI, Wanfangdata, Vip and China Biology Medicine databases by computer. The Chinese keywords was coronary-caval shunt, coronary vein-caval vein shunt, gastric coronary vein-inferior vena cava shunt and gastric coronary vein-caval vein shunt. The data were extracted from the literatures, and clinical characteristics, surgical indexes and clinical prognosis were analyzed. Preoperative and postoperative data were compared using t test.

Results

A total of 8 literatures related to coronary-caval shunt were searched out, including 60 patients. Forty-four were males and 16 were females, aged 19-62 years old with a median age of 43 years old. Among them, 80% (48/60) of the patients had a medical history of upper gastrointestinal bleeding. Twenty-seven cases were classified as grade A of preoperative liver function Child-Pugh grade, 29 were classified as grade B, and 4 were not classified. The anastomosis between gastric coronary vein and inferior vena cava was performed by bypass vessels in 88% (53/60) of the patients, and the anastomosis was performed without bypass vessels in the other 12% (7/60). In the selection of bypass vessels, splenic vein was utilized in 31 cases, great saphenous vein in 7, internal jugular vein in 4, external jugular vein in 4, artificial vessel in 4, internal spermatic vein in 2 and right gastroepiploic vein in 1. The median decrease of portal venous pressure and gastric coronary venous pressure was respectively 3.0 (1.4-7.2) and 13.0 (11.0-14.0) cmH2O (1 cmH2O=0.098 kPa) after coronary-caval shunt. Fifty-nine patients were followed up for 65.4 (0.3-228.0) months. Upper gastrointestinal bleeding was observed in 5 cases after surgery and hepatic encephalopathy in 1. Ascites, liver failure, bypass vascular thrombosis or other complications were not observed.

Conclusions

Coronary-caval shunt exerts a significant effect on lowering regional blood pressure with a low incidence of gastrointestinal rebleeding and hepatic encephalopathy. It is an efficacious therapy for patients with recurrent upper gastrointestinal bleeding.

图1 冠腔分流术手术示意图及CT血管成像资料
表1 冠腔分流术患者的临床特征
表2 冠腔分流术后患者的临床疗效
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