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中华肝脏外科手术学电子杂志 ›› 2021, Vol. 10 ›› Issue (03) : 314 -317. doi: 10.3877/cma.j.issn.2095-3232.2021.03.017

所属专题: 文献

临床研究

非寄生虫性肝囊肿临床特征及干预治疗影响因素分析
马锋1, 冯文宇2, 张谞丰3, 牟怡平4, 刘学民3, 李宇3, 张晓刚3, 仵正3, 王博3, 吴荣谦1, 于良3, 李强2, 吕毅3,()   
  1. 1. 710061 西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心 陕西省再生医学与外科工程研究中心
    2. 710061 西安交通大学医学部公共卫生学院流行病与卫生统计教研室
    3. 710061 西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心 陕西省再生医学与外科工程研究中心;710061 西安交通大学第一附属医院肝胆外科
    4. 710061 西安交通大学第一附属医院医疗信息管理办公室
  • 收稿日期:2021-03-11 出版日期:2021-06-10
  • 通信作者: 吕毅
  • 基金资助:
    陕西省科技厅重点研发计划项目(2019ZDLSF01-02-02); 西安交通大学第一附属医院新医疗新技术项目(XJYFY-2018ZD1)

Analysis of clinical characteristics of non-parasitic hepatic cysts and influencing factors for therapies

Feng Ma1, Wenyu Feng2, Xufeng Zhang3, Yiping Mou4, Xuemin Liu3, Yu Li3, Xiaogang Zhang3, Zheng Wu3, Bo Wang3, Rongqian Wu1, Liang Yu3, Qiang Li2, Yi Lyu3,()   

  1. 1. National and Local Joint Engineering Research Center of Precision Surgery and Regenerative Medicine, Shaanxi Provincial Research Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an 710061, China
    2. Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China
    3. National and Local Joint Engineering Research Center of Precision Surgery and Regenerative Medicine, Shaanxi Provincial Research Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an 710061, China; Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an 710061, China
    4. Medical Information Management Office, First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an 710061, China
  • Received:2021-03-11 Published:2021-06-10
  • Corresponding author: Yi Lyu
引用本文:

马锋, 冯文宇, 张谞丰, 牟怡平, 刘学民, 李宇, 张晓刚, 仵正, 王博, 吴荣谦, 于良, 李强, 吕毅. 非寄生虫性肝囊肿临床特征及干预治疗影响因素分析[J]. 中华肝脏外科手术学电子杂志, 2021, 10(03): 314-317.

Feng Ma, Wenyu Feng, Xufeng Zhang, Yiping Mou, Xuemin Liu, Yu Li, Xiaogang Zhang, Zheng Wu, Bo Wang, Rongqian Wu, Liang Yu, Qiang Li, Yi Lyu. Analysis of clinical characteristics of non-parasitic hepatic cysts and influencing factors for therapies[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2021, 10(03): 314-317.

目的

探讨非寄生虫性肝囊肿临床特点、治疗及影响干预治疗的因素。

方法

回顾性分析2008年1月至2020年4月西安交通大学第一附属医院收治的591例非寄生虫性肝囊肿患者临床资料。患者签署知情同意书,符合医学伦理学规定。记录患者人口学资料及临床特征,包括年龄、性别、囊肿大小、囊肿位置、治疗方式等。治疗的影响因素分析采用多因素Logistic回归分析。

结果

男性患者占39.4% (233/591),女性占60.6% (358/591);年龄50~70岁,中位年龄61岁。单发性肝囊肿194例,多发性肝囊肿397例。有临床症状者占56.5%(334/591),主要症状为腹痛、腹胀。治疗干预494例,其中超声引导下肝囊肿穿刺抽吸57例,腹腔镜肝囊肿开窗引流术369例,开腹肝囊肿开窗引流术68例。囊肿直径≥8 cm是疗效的独立影响因素(OR=5.471,95%CI:3.347~8.942;P<0.05)。

结论

非寄生虫性肝囊肿好发于中老年女性患者,所有患者均以多发囊肿为主。开窗引流术为主要治疗方式,对于肝囊肿直径≥8 cm建议积极治疗。

Objective

To investigate the clinical characteristics, treatments and influencing factors for the therapies of non-parasitic hepatic cysts.

Methods

Clinical data of 591 patients with non-parasitic hepatic cysts admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January 2008 to April 2020 were retrospectively analyzed. The informed consents of all patients were obtained and the local ethical committee approval was received. Demographic data and clinical characteristics including age, sex, cyst size, cyst location and treatments were recorded. The influencing factors of treatments were analyzed by multivariate Logistic regression analysis.

Results

Among them, the proportion of male patients was 39.4%(233/591) and 60.6%(358/591) for the female counterparts, all aged from 50 to 70 years with a median age of 61 years. 194 patients were diagnosed with single hepatic cyst and 397 cases with multiple hepatic cysts. The proportion of patients presenting with clinical symptoms was 56.5%(334/591). The main symptoms included abdominal pain and distension. 494 patients received treatments, including 57 cases of ultrasound-guided hepatic cyst aspiration, 369 cases of laparoscopic hepatic cyst fenestration and drainage and 68 cases of open hepatic cyst fenestration and drainage. The cyst diameter of ≥8 cm was an independent influencing factor for the therapeutic effect (OR=5.471, 95%CI: 3.347-8.942; P<0.05).

Conclusions

Non-parasitic hepatic cysts are more prevalent in middle-aged and elderly women, and patients are mainly with multiple lesions. Fenestration and drainage is the primary treatment. Active treatment is recommended for the hepatic cyst with a diameter of ≥8 cm.

图1 591例非寄生虫性肝囊肿患者年龄分布
表1 不同性别的非寄生虫性肝囊肿患者一般临床特征
表2 影响非寄生虫性肝囊肿患者干预治疗的相关因素
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