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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (01) : 29 -33. doi: 10.3877/cma.j.issn.2095-3232.2023.01.006

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肝细胞癌自发性破裂出血危险因素及预测模型研究现状
王小兵1, 邓卓凡2, 龚建平2,()   
  1. 1. 401120 重庆市渝北区人民医院普通外科
    2. 400010 重庆医科大学附属第二医院肝胆外科
  • 收稿日期:2022-11-04 出版日期:2023-02-10
  • 通信作者: 龚建平

Risk factors of spontaneous rupture of hepatocellular carcinoma and current research of its prognostic model

Xiaobing Wang1, Zhuofan Deng2, Jianping Gong2()   

  • Received:2022-11-04 Published:2023-02-10
  • Corresponding author: Jianping Gong
引用本文:

王小兵, 邓卓凡, 龚建平. 肝细胞癌自发性破裂出血危险因素及预测模型研究现状[J]. 中华肝脏外科手术学电子杂志, 2023, 12(01): 29-33.

Xiaobing Wang, Zhuofan Deng, Jianping Gong. Risk factors of spontaneous rupture of hepatocellular carcinoma and current research of its prognostic model[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(01): 29-33.

肝细胞癌(HCC)是世界上最常见的恶性肿瘤之一,其发病率在全球范围内呈上升趋势[1,2]。2020年全球癌症组织最新研究数据显示,HCC全球新发患者数为84.1万,位居全球所有恶性肿瘤发病率的第6位,死亡率居全球恶性肿瘤的第4位,据估计,到2025年全球每年将有超过100万HCC患者[3]。HCC是目前我国第4位常见恶性肿瘤及第2位肿瘤致死病因[4]。HCC自发性破裂出血是HCC少见但致命的严重并发症,美国癌症联合委员会和国际抗癌联盟定义为T4病变[5]。HCC发生率与地域有较大相关性,在西方国家HCC发生率不到3%,而在亚洲地区其发生率高达12%~14%[6]。HCC自发性破裂可导致大量腹腔出血,急性期病死率高达25%~75%,是除肿瘤进展和肝衰竭外的第三大常见HCC死亡原因[7]。患者出血后常导致肿瘤腹腔广泛种植和腹膜转移,降低患者远期生存率[8,9]。此外,根据HCC肝移植的肝脏分配政策,HCC自发性破裂出血是肝移植的禁忌证之一[10]。当HCC自发性破裂出血发生时,大多数早期HCC患者失去了根治性治疗的机会。

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