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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (06) : 602 -607. doi: 10.3877/cma.j.issn.2095-3232.2023.06.003

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原发性肝癌转化治疗焦点问题探讨
魏小勇()   
  1. 330029 南昌,江西省肿瘤医院肝胆肿瘤外科
  • 收稿日期:2023-07-27 出版日期:2023-12-10
  • 通信作者: 魏小勇
  • 基金资助:
    江西省卫生健康委科技计划项目(SKJP220219292); 江西省重点研发计划项目(20161ACG70016)

Discussion on the focus issues of conversion therapy for primary liver cancer

Xiaoyong Wei()   

  • Received:2023-07-27 Published:2023-12-10
  • Corresponding author: Xiaoyong Wei
引用本文:

魏小勇. 原发性肝癌转化治疗焦点问题探讨[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 602-607.

Xiaoyong Wei. Discussion on the focus issues of conversion therapy for primary liver cancer[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 602-607.

原发性肝癌(肝癌)是常见的恶性肿瘤之一,我国是肝癌的高发地区,其年新发病例数及死亡病例数占全球近一半[1]。早期肝癌患者可通过手术等治疗获得治愈,但因为肝癌发病隐匿,早期无特异性症状,约70%肝癌患者初诊即为中晚期,无法行根治性手术切除治疗,从而生存时间短,预后差。近年来,随着新的靶向及免疫药物的不断发展,肝癌的系统治疗取得显著进步,使肝癌的治疗格局发生了较大转变。不可手术切除的中晚期肝癌患者可以经过介入、靶向、免疫等多模式的综合治疗后使肿瘤缩小或降期,部分患者可以获得根治性手术切除机会。转化治疗使越来越多的中晚期肝癌患者从中获益,很多患者明显延长了总体生存期(OS),甚至获得了治愈。因此肝癌的转化治疗也成为近年来的研究热点,但转化治疗现在仍处于不断探索的阶段。本文主要对肝癌转化治疗的焦点问题,如适合人群、方案的选择、手术时机、手术必要性及后续治疗方案等方面进行探讨,以期为中晚期肝癌的转化治疗带来参考。

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