探讨术前胆道引流（PBD）对壶腹周围癌患者术后并发症和远期生存的影响。

回顾性分析2016年1月至2018年6月在西安交通大学第一附属医院行胰十二指肠切除术的114例壶腹周围癌患者临床资料。其中男75例，女39例；年龄39~78岁，中位年龄62岁。壶腹癌55例，远端胆管癌52例，十二指肠乳头癌7例。患者均签署知情同意书，符合医学伦理学规定。根据术前是否进行PBD，将患者分为PBD组（36例）和未引流组（78例）。比较两组围手术期、术后并发症和远期生存情况。两组围手术期指标比较采用t检验或Mann-Whitney U检验，并发症发生率比较采用χ²检验。生存分析采用Kaplan-Meier法和Log-rank检验。

PBD组术后TB中位数为110（132）μmol/L，明显小于未引流组的156（117）μmol/L（Z=-2.588，P<0.05）。PBD组术后TB变化值为43（163）μmol/L，明显大于未引流组的25（87）μmol/L（Z=2.140，P<0.05）。PBD组术后总并发症发生率为72%（56/78），未引流组为67%（24/36），差异无统计学意义（χ²=0.310，P>0.05）。生存分析显示，PBD组中位生存期为24个月，未引流组为20个月，两组总体生存率比较差异无统计学意义（χ²=0.551，P>0.05）。

对于壶腹周围癌患者，术前PBD仅能明显改善黄疸情况，而对术后并发症和长期生存并无明显获益，不推荐常规PBD减黄。

To evaluate the effect of preoperative biliary drainage (PBD) on postoperative complications and long-term survival of patients with periampullary cancer.

Clinical data of 114 patients with periampullary cancer who underwent pancreaticoduodenectomy in the First Affiliated Hospital of Xi'an Jiaotong University from January 2016 to June 2018 were retrospectively analyzed. Among them, 75 patients were male and 39 female, aged from 39 to 78 years, with a median age of 62 years. 55 patients were diagnosed with ampullary carcinoma, 52 cases of distal cholangiocarcinoma and 7 cases of carcinoma of the duodenal papilla. The informed consents of all patients were obtained and the local ethical committee approval was received. All patients were divided into the PBD (n=36) and non-drainage groups (n=78) according to whether preoperative PBD was performed. Perioperative and postoperative complications and long-term survival were compared between two groups. Perioperative parameters betweentwo groups were compared by t test or Mann-Whitney U test. The incidence of complications was compared byChi-square test. Survival analysis was performed by Kaplan-Meier method and Log-rank test.

In the PBD group, the median postoperative TB level was 110(132) μmol/L, significantly lower than 156(117) μmol/L in the non-drainage group (Z=-2.588, P<0.05). The change value of postoperative TB level in the PBD group was 43(163) μmol/L, significantly higher than 25(87) μmol/L in the non-drainage group (Z=2.140, P<0.05). In the PBD group, the total incidence of postoperative complications was 72%(56/78), and 67%(24/36) in the non-drainage group, where no significant difference was observed (χ²=0.310, P>0.05). Survival analysis showed that the median overall survival was 24 months in the PBD group and 20 months in non-drainage group, where no significant difference was observed between two groups (χ²=0.551, P>0.05).

For patients with periampullary cancer, preoperative PBD can significantly mitigate jaundice, whereas it brings no significant benefits for postoperative complications and long-term survival. Hence, PBD is not routinely recommended for patients with periampullary cancer complicated with obstructive jaundice.