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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 239 -242. doi: 10.3877/cma.j.issn.2095-3232.2023.02.022

综述

N6-甲基腺苷表观转录组学在原发性肝癌中的研究进展
杨小周1, 赵华栋1,()   
  1. 1. 710038 西安,中国人民解放军空军军医大学第二附属医院普通外科
  • 收稿日期:2022-12-25 出版日期:2023-03-28
  • 通信作者: 赵华栋
  • 基金资助:
    国家自然科学基金(81172287); 陕西省自然科学基础研究计划项目(2020JM-337)

Research progress of N6-methyladenosine epitranscriptomics in hepatocellular carcinoma

Xiaozhou Yang1, Huadong Zhao1()   

  • Received:2022-12-25 Published:2023-03-28
  • Corresponding author: Huadong Zhao
引用本文:

杨小周, 赵华栋. N6-甲基腺苷表观转录组学在原发性肝癌中的研究进展[J]. 中华肝脏外科手术学电子杂志, 2023, 12(02): 239-242.

Xiaozhou Yang, Huadong Zhao. Research progress of N6-methyladenosine epitranscriptomics in hepatocellular carcinoma[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(02): 239-242.

除DNA和组蛋白外,RNA(mRNA、tRNA、snRNA等)在不同的位点存在数百种不同种类的修饰。早期对RNA修饰的研究主要集中在mRNA的5'端。N6-甲基腺苷(N6-methyladenosine,m6A)已被认为是哺乳动物mRNA和非编码RNA中含量最丰富的化学修饰,并参与调节多种细胞过程[1]。由于RNA结构和功能的复杂性,深入了解m6A生物学作用仍然极富挑战性。最近研究表明转录后的RNA修饰过程是可逆且动态变化,提示其可能具有类似于DNA和组蛋白修饰的潜在调节能力。这种可逆性修饰与DNA和组蛋白修饰类似,是调控基因表达的重要机制之一。研究这些可逆RNA修饰的前景和功能现在正成为一个新的研究前沿,被称为"RNA表观遗传学"或"表观转录组学"[2]。m6A修饰表观转录组学的研究对原发性肝癌(肝癌)的预后、治疗和术后评估有着广阔的应用前景。本篇综述重点介绍m6A修饰调节及其在肝癌发展和治疗中作用的最新进展。

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