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中华肝脏外科手术学电子杂志 ›› 2025, Vol. 14 ›› Issue (04) : 508 -514. doi: 10.3877/cma.j.issn.2095-3232.2025.04.002

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结直肠癌肝转移肝移植治疗研究进展
鲁旭, 李华()   
  1. 510630 广州,中山大学附属第三医院肝脏外科暨肝移植中心
  • 收稿日期:2025-01-14 出版日期:2025-08-10
  • 通信作者: 李华
  • 基金资助:
    中山大学附属第三医院"五个五"工程项目(2023ww105); 广州市科技计划项目(02A004999000186)

Research progress in liver transplantation for colorectal liver metastasis

Xu Lu, Hua Li()   

  1. Department of Liver Surgery & Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
  • Received:2025-01-14 Published:2025-08-10
  • Corresponding author: Hua Li
引用本文:

鲁旭, 李华. 结直肠癌肝转移肝移植治疗研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(04): 508-514.

Xu Lu, Hua Li. Research progress in liver transplantation for colorectal liver metastasis[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 14(04): 508-514.

结直肠癌肝转移(CRLM)是肠道肿瘤患者常见且严重的并发症,显著降低了患者的生存率与生活质量。既往的治疗方式主要包括全身化疗、介入及靶向药物治疗,但整体预后较差。近年来,随着肝移植技术的进步和多中心临床研究的开展,肝移植逐渐成为治疗CRLM的潜在选择。然而,结直肠癌肝移植的适应证、禁忌证及预后因素等仍需进一步研究,以确保患者能够获得最佳的治疗效果。本文旨在阐述CRLM的生物学机制及肝移植在治疗中的应用潜力,为肠癌患者的临床管理提供新的思路与参考,推动该领域的深入研究与实践。

Colorectal liver metastasis (CRLM) is a common and severe complication in patients with intestinal tumors, which significantly reduces the survival rate and the quality of life of patients. Traditional treatments mainly include systemic chemotherapy, interventional therapy and targeted drug therapy, whereas the overall prognosis is relatively poor. In recent years, with the advancement in liver transplantation and the launching of multi-center clinical research, liver transplantation has gradually become a potential therapeutic option for CRLM. However, the indications, contraindications and prognostic factors of liver transplantation for colorectal cancer should be further investigated to guarantee that patients can obtain the optimal efficacy. In this article, the biological mechanism of CRLM and the potential application of liver transplantation in the treatment of CRLM were illustrated, providing novel ideas and reference for clinical management of patients with colorectal cancer and promoting in-depth research and practice in this field.

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