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中华肝脏外科手术学电子杂志 ›› 2026, Vol. 15 ›› Issue (05) : 718 -723. doi: 10.3877/cma.j.issn.2095-3232.2026.05.006

前沿与争鸣

抗体偶联药物在胆道肿瘤治疗中的研究进展
唐流康, 陈明政, 栗玉龙, 郑玉廷, 谢峰()   
  1. 200438 海军军医大学附属第三医院(上海东方肝胆外科医院)胆道三科
  • 收稿日期:2025-12-02 出版日期:2026-10-10
  • 通信作者: 谢峰
  • 基金资助:
    上海市自然科学基金(16ZR1449200); 上海申康医院发展中心临床科技创新项目(SHDC12017X14); 上海申康医院发展中心临床研究型医师项目(SHDC2022CRD047)

Research progress in antibody-drug conjugate therapy for biliary tract cancer

Liukang Tang, Mingzheng Chen, Yulong Li, Yuting Zheng, Feng Xie()   

  1. Department Ⅲ of Biliary Tract Surgery, the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai 200438, China
  • Received:2025-12-02 Published:2026-10-10
  • Corresponding author: Feng Xie
引用本文:

唐流康, 陈明政, 栗玉龙, 郑玉廷, 谢峰. 抗体偶联药物在胆道肿瘤治疗中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(05): 718-723.

Liukang Tang, Mingzheng Chen, Yulong Li, Yuting Zheng, Feng Xie. Research progress in antibody-drug conjugate therapy for biliary tract cancer[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2026, 15(05): 718-723.

胆道恶性肿瘤(BTC)是一类起源于胆管上皮的常见恶性肿瘤,具有高度异质性、侵袭性强、预后差等特点,手术治疗是唯一可实现根治的治疗方式。然而60%~80%的患者就诊时肿瘤已处于晚期,手术治疗效果有限。近年来随着二代基因测序技术的进步及新的临床药物的研发,免疫及靶向治疗逐渐成为临床治疗选择的新方向,而抗体偶联药物(ADC)具有“精准靶向+高效杀伤”的双重特性,逐渐成为BTC治疗领域的研究热点。本文就ADC类新药在BTC治疗的研究进展做一综述。

Biliary tract cancer (BTC) is a common malignancy originating from the biliary epithelia, characterized by high heterogeneity, strong invasiveness and poor prognosis. Surgical resection remains the only radical treatment. However, 60%-80% of BTC patients are diagnosed at advanced stage upon admission, limiting surgical efficacy. In recent years, with the advancement of next-generation sequencing and the development of novel clinical drugs, immunotherapy and targeted therapy have gradually emerged as new directions in clinical treatment. Antibody-drug conjugate (ADC), with dual characteristics of "precise targeting + efficient killing," has gradually become a research hotspot in the treatment of BTC. In this article, research progress in novel ADC drugs in the treatment of BTC was reviewed.

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