Epidemiological investigation of polypoid lesions of gallbladder and influence factors of disease progression

doi:10.3877/cma.j.issn.2095-3232.2023.01.018

Abstract

Abstract:

Objective

To investigate the epidemiological characteristics of polypoid lesions of the gallbladder (PLG) and influence factors of PLG progression.

Methods

Clinical data of 627 PLG patients treated in the No.909 Hospital of Joint Logistic Support Forces of PLA from January 2019 to December 2020 were retrospectively analyzed. Among them, 343 patients were male and 284 female, aged from 21 to 70 years, with a median age of 42 years. 300 healthy subjects receiving physical examination in January 2020 were enrolled as healthy controls. The informed consents of all patients were obtained and the local ethical committee approval was received. The epidemiological characteristics of PLG patients were analyzed. Baseline data of PLG patients and healthy controls were compared. According to the follow-up results, PLG patients were divided into the progression and non-progression groups. The rates of two groups were compared by Chi-square test. The influence factors of PLG progression were identified by multivariate Logistic regression analysis.

Results

Among 627 PLG patients, the proportion of patients aged30-40 years was the highest (38.4%), followed by 40-50 years (34.8%). The male-to-female ratio was 1.21∶1. The proportion of office staff was the highest up to 58.4%. The proportion of single PLG was 53.3%, slightly higher than 46.7% of multiple PLG. The proportion of PLG with a diameter of 1-6 mm was 63.3%. Non-wide basal PLG accounted for 88.4%. The proportion of diabetes mellitus, obesity, fatty liver and elevated blood lipids in PLG patients was significantly higher than that in healthy controls (χ²=13.646, 21.567, 17.758, 19.046; P<0.05). Multivariate analysis showed that wide basal PLG, elevated blood lipids, increased BMI and long-term staying up late were the independent risk factors for PLG progression (OR=2.366, 3.367, 4.124, 2.373; P<0.05).

Conclusions

Wide basal PLG, elevated blood lipids, increased BMI and long-term staying up late are the risk factors for PLG progression.

Key words: Gallbladder, Polyps, Epidemiology, Risk factors

Haisen Zhang, Jinbao Ye, Pengfei Gao. Epidemiological investigation of polypoid lesions of gallbladder and influence factors of disease progression[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(01): 91-95.

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References 20

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临床指标		例数	占比（%）
年龄（岁）
	20~30	43	6.9
	30~40	241	38.4
	40~50	218	34.8
	50~60	94	15.0
	60~70	31	4.9
性别
	男	343	54.7
	女	284	45.3
职业
	学生	28	4.5
	农民	107	17.1
	工人	126	20.1
	职员	366	58.4
息肉数目
	单个	334	53.3
	多个	293	46.7
息肉大小（mm）
	1~6	397	63.3
	6~8	173	27.6
	8~9	57	9.1
息肉形态
	宽基底	73	11.61
	非宽基底	554	88.4
糖尿病		104	16.6
吸烟		275	43.9
饮酒		298	47.5
肥胖		301	48.0
脂肪肝		244	39.9
胆囊息肉家族史		52	8.3

临床指标		例数	占比（%）
年龄（岁）
	20~30	43	6.9
	30~40	241	38.4
	40~50	218	34.8
	50~60	94	15.0
	60~70	31	4.9
性别
	男	343	54.7
	女	284	45.3
职业
	学生	28	4.5
	农民	107	17.1
	工人	126	20.1
	职员	366	58.4
息肉数目
	单个	334	53.3
	多个	293	46.7
息肉大小（mm）
	1~6	397	63.3
	6~8	173	27.6
	8~9	57	9.1
息肉形态
	宽基底	73	11.61
	非宽基底	554	88.4
糖尿病		104	16.6
吸烟		275	43.9
饮酒		298	47.5
肥胖		301	48.0
脂肪肝		244	39.9
胆囊息肉家族史		52	8.3

因素	PLG组	健康对照组	统计值	P值
年龄（岁，±s）	44±12	42±9	t=1.573	0.647
性别（男/女，例）	343/284	169/131	χ²=0.846	0.537
糖尿病（例）	104	24	χ²=13.646	<0.001
吸烟（例）	275	129	χ²=0.674	0.857
饮酒（例）	298	116	χ²=5.575	0.037
肥胖（例）	301	93	χ²=21.567	<0.001
脂肪肝（例）	244	84	χ²=17.758	<0.001
血脂升高（例）	263	92	χ²=19.046	<0.001
乙肝（例）	77	44	χ²=0.604	0.767

因素	PLG组	健康对照组	统计值	P值
年龄（岁，±s）	44±12	42±9	t=1.573	0.647
性别（男/女，例）	343/284	169/131	χ²=0.846	0.537
糖尿病（例）	104	24	χ²=13.646	<0.001
吸烟（例）	275	129	χ²=0.674	0.857
饮酒（例）	298	116	χ²=5.575	0.037
肥胖（例）	301	93	χ²=21.567	<0.001
脂肪肝（例）	244	84	χ²=17.758	<0.001
血脂升高（例）	263	92	χ²=19.046	<0.001
乙肝（例）	77	44	χ²=0.604	0.767

因素	进展组	无进展组	统计值	P值
年龄（岁，±s）	44±8	44±8	t=0.864	0.787
性别（男/女，例）	36/26	289/237	χ²=1.036	0.183
单发（例）	33	281	χ²=1.142	0.201
宽基底息肉（例）	11	61	χ²=8.467	<0.001
糖尿病（例）	38	61	χ²=19.473	<0.001
吸烟（例）	28	228	χ²=0.736	0.610
饮酒（例）	27	239	χ²=0.773	0.662
肥胖（例）	42	233	χ²=18.646	<0.001
脂肪肝（例）	30	197	χ²=16.386	<0.001
血脂升高（例）	34	84	χ²=21.477	<0.001
乙肝（例）	8	66	χ²=0.537	0.848
胆囊息肉家族史（例）	4	39	χ²=0.615	0.773
BMI升高（例）	30	137	χ²=23.248	<0.001
长期熬夜（例）	20	57	χ²=22.637	<0.001

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