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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (01) : 91 -95. doi: 10.3877/cma.j.issn.2095-3232.2023.01.018

临床研究

胆囊息肉流行病学调查及其进展影响因素分析
张海森1, 叶金宝2, 高鹏飞1,()   
  1. 1. 363000 福建省漳州市,中国人民解放军联勤保障部队第九〇九医院(厦门大学附属东南医院)普通外科
    2. 363000 福建省漳州市,中国人民解放军联勤保障部队第九〇九医院(厦门大学附属东南医院)检验科
  • 收稿日期:2022-09-06 出版日期:2023-02-10
  • 通信作者: 高鹏飞
  • 基金资助:
    福建省自然科学基金(2020J01133)

Epidemiological investigation of polypoid lesions of gallbladder and influence factors of disease progression

Haisen Zhang1, Jinbao Ye2, Pengfei Gao1,()   

  1. 1. Department of General Surgery, No.909 Hospital of Joint Logistic Support Forces of PLA (Southeast Hospital Affiliated to Xiamen University), Zhangzhou 363000, China
    2. Clinical Laboratory, No.909 Hospital of Joint Logistic Support Forces of PLA (Southeast Hospital Affiliated to Xiamen University), Zhangzhou 363000, China
  • Received:2022-09-06 Published:2023-02-10
  • Corresponding author: Pengfei Gao
引用本文:

张海森, 叶金宝, 高鹏飞. 胆囊息肉流行病学调查及其进展影响因素分析[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(01): 91-95.

Haisen Zhang, Jinbao Ye, Pengfei Gao. Epidemiological investigation of polypoid lesions of gallbladder and influence factors of disease progression[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(01): 91-95.

目的

探讨胆囊息肉(PLG)的流行病学特征及其进展影响因素。

方法

回顾性分析2019年1月至2020年12月在中国人民解放军联勤保障部队第九〇九医院就诊的627例PLG患者临床资料。其中男343例,女284例;年龄21~70岁,中位年龄42岁。同时收集2020年1月300例健康体检者作为健康对照。所有入组人员患者均签署知情同意书,符合医学伦理学规定。分析PLG患者的流行病学特征,比较PLG患者和健康对照者的一般资料。根据随访情况,将PLG患者分为进展组和无进展组。两组率的比较采用χ2检验。PLG进展的影响因素分析采用多因素Logistic回归分析。

结果

627例PLG患者中,30~40岁年龄段占比最高,其次为40~50岁年龄段,分别为38.4%和34.8%;男性略高于女性,男女占比为1.21∶1;办公室职员占比最高,为58.4%;单发息肉占比略高于多发息肉,分别为53.3%、46.7%;息肉直径在1~6 mm内占比63.3%;非宽基底型息肉占88.4%。PLG患者糖尿病、肥胖、脂肪肝、血脂升高占比明显高于健康对照者(χ2=13.646,21.567,17.758,19.046;P<0.05)。多因素分析显示,宽基底型息肉、血脂升高、BMI升高、长期熬夜是PLG进展的独立危险因素(OR=2.366,3.367,4.124,2.373;P<0.05)。

结论

宽基底型息肉、血脂升高、BMI升高和长期熬夜是PLG进展的危险因素。

Objective

To investigate the epidemiological characteristics of polypoid lesions of the gallbladder (PLG) and influence factors of PLG progression.

Methods

Clinical data of 627 PLG patients treated in the No.909 Hospital of Joint Logistic Support Forces of PLA from January 2019 to December 2020 were retrospectively analyzed. Among them, 343 patients were male and 284 female, aged from 21 to 70 years, with a median age of 42 years. 300 healthy subjects receiving physical examination in January 2020 were enrolled as healthy controls. The informed consents of all patients were obtained and the local ethical committee approval was received. The epidemiological characteristics of PLG patients were analyzed. Baseline data of PLG patients and healthy controls were compared. According to the follow-up results, PLG patients were divided into the progression and non-progression groups. The rates of two groups were compared by Chi-square test. The influence factors of PLG progression were identified by multivariate Logistic regression analysis.

Results

Among 627 PLG patients, the proportion of patients aged30-40 years was the highest (38.4%), followed by 40-50 years (34.8%). The male-to-female ratio was 1.21∶1. The proportion of office staff was the highest up to 58.4%. The proportion of single PLG was 53.3%, slightly higher than 46.7% of multiple PLG. The proportion of PLG with a diameter of 1-6 mm was 63.3%. Non-wide basal PLG accounted for 88.4%. The proportion of diabetes mellitus, obesity, fatty liver and elevated blood lipids in PLG patients was significantly higher than that in healthy controls (χ2=13.646, 21.567, 17.758, 19.046; P<0.05). Multivariate analysis showed that wide basal PLG, elevated blood lipids, increased BMI and long-term staying up late were the independent risk factors for PLG progression (OR=2.366, 3.367, 4.124, 2.373; P<0.05).

Conclusions

Wide basal PLG, elevated blood lipids, increased BMI and long-term staying up late are the risk factors for PLG progression.

表1 胆囊息肉患者流行病学分析
表2 PLG组与健康对照组一般情况比较
表3 胆囊息肉进展单因素分析
表4 胆囊息肉进展多因素Logistics回归分析
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