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中华肝脏外科手术学电子杂志 ›› 2024, Vol. 13 ›› Issue (05) : 640 -643. doi: 10.3877/cma.j.issn.2095-3232.2024.05.009

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胰腺癌新辅助化疗现状和治疗策略
王军华1,(), 王锐炫1   
  1. 1. 528000 广东省佛山市第一人民医院胆胰外科
  • 收稿日期:2024-06-30 出版日期:2024-10-10
  • 通信作者: 王军华
  • 基金资助:
    佛山市"十四五"医学重点专科和培育专科(FSGSP14500)

Current status and treatment strategy of neoadjuvant chemotherapy for pancreatic cancer

Junhua Wang1,(), Ruixuan Wang1   

  1. 1. Department of Biliary and Pancreatic Surgery, the First People's Hospital of Foshan, Foshan 528000, China
  • Received:2024-06-30 Published:2024-10-10
  • Corresponding author: Junhua Wang
引用本文:

王军华, 王锐炫. 胰腺癌新辅助化疗现状和治疗策略[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 640-643.

Junhua Wang, Ruixuan Wang. Current status and treatment strategy of neoadjuvant chemotherapy for pancreatic cancer[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 640-643.

胰腺导管腺癌(PDAC)患者最好的治疗方法是手术切除原发病灶加全身化疗,联合治疗方式能提供更好的总体生存期(OS)。大多数患者术后因微转移而复发,而新辅助化疗可改善OS。约20%的不可切除PDAC患者可能会在4~6个月的诱导治疗联合化疗后进行切除,从而改善其OS。本文阐述目前PDAC不同临床阶段的治疗策略,以期为提升我国胰腺癌整体治疗水平提供参考。

Surgical resection of the primary lesion combined with systemic chemotherapy is the optimal treatment for pancreatic ductal adenocarcinoma (PDAC). Combined treatment can yield longer overall survival (OS). Most patients recur due to postoperative micrometastasis, and neoadjuvant chemotherapy can improve OS. Approximately 20% of patients with unresectable PDAC might undergo resection after 4-6 month induction therapy combined with chemotherapy, thereby improving the OS. We described current treatment strategies for PDAC in different clinical stages, aiming to provide a reference for enhancing the overall treatment level for pancreatic cancer in China.

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