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中华肝脏外科手术学电子杂志 ›› 2025, Vol. 14 ›› Issue (04) : 515 -521. doi: 10.3877/cma.j.issn.2095-3232.2025.04.003

述评

肝细胞癌新辅助治疗进展
杨钰泽1,2, 徐家豪1, 杨一石3, 王明达1, 杨田1,2,()   
  1. 1200438 海军军医大学第三附属医院(上海东方肝胆外科医院)肝外二科
    2130021 长春,吉林大学第一医院普通外科中心肝胆胰外一科
    3226019 江苏省南通大学公共卫生学院
  • 收稿日期:2025-02-23 出版日期:2025-08-10
  • 通信作者: 杨田
  • 基金资助:
    国家自然科学基金(81972726); 上海市自然科学基金(22ZR1477900)

Progress in neoadjuvant therapy for hepatocellular carcinoma

Yuze Yang1,2, Jiahao Xu1, Yishi Yang3, Mingda Wang1, Tian Yang1,2,()   

  1. 1Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), Shanghai 200438, China
    2Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun 130021, China
    3School of Public Health, Nantong University, Nantong 226019, China
  • Received:2025-02-23 Published:2025-08-10
  • Corresponding author: Tian Yang
引用本文:

杨钰泽, 徐家豪, 杨一石, 王明达, 杨田. 肝细胞癌新辅助治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(04): 515-521.

Yuze Yang, Jiahao Xu, Yishi Yang, Mingda Wang, Tian Yang. Progress in neoadjuvant therapy for hepatocellular carcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 14(04): 515-521.

肝细胞癌(HCC)作为全球第三大致死恶性肿瘤,其高发病率和死亡率凸显了治疗的紧迫需求。尽管手术切除和肝移植为HCC提供了根治可能,但由于早期诊断率低,大多数患者仍面临高复发风险。最新的治疗策略,特别是免疫检查点抑制剂(ICIs)的使用,为改善预后开辟了新的道路。然而,新辅助治疗在实现HCC早期治疗方面的潜力尚未充分挖掘。本文深入探讨了新辅助治疗在可切除HCC治疗中的作用、面临的挑战及未来发展方向,旨在为HCC患者提供更为全面和有效的治疗方案。通过分析新辅助治疗的现有证据和探索其在减少复发及延长生存期方面的潜力,为HCC治疗领域带来创新思路。

Hepatocellular carcinoma (HCC) is the third most deadly malignancy worldwide, and its high incidence and mortality rates highlight the urgent need for treatment. Although surgical resection and liver transplantation provide the possibility of radical cure for HCC, most patients still face a high risk of recurrence due to low diagnostic rate during the early stage. The latest treatment strategies, especially the use of immune checkpoint inhibitors (ICIs), have paved a new way to improve clinical prognosis. However, the potential of neoadjuvant therapy in early treatment of HCC has not been fully unleashed. In this article, the role, challenges and future development direction of neoadjuvant therapy in the treatment of resectable HCC were illustrated, aiming to provide a more comprehensive and effective treatment for HCC patients. The existing evidence of neoadjuvant therapy was analyzed and its potential in reducing recurrence and prolonging survival was investigated to bring innovative ideas for the treatment of HCC.

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