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中华肝脏外科手术学电子杂志 ›› 2025, Vol. 15 ›› Issue (01) : 21 -27. doi: 10.3877/cma.j.issn.2095-3232.2026.01.005

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肝癌免疫治疗策略及其在围手术期中应用进展
尹鹏飞1,2, 吴堃1,2, 王槐志1,2,3, 蔡磊1,2,3,()   
  1. 1 401147 重庆大学附属人民医院肝胆胰腺外科研究所
    2 401147 重庆市人民医院肝胆胰腺外科研究所
    3 401147 重庆,肝胆胰疾病智慧诊疗工程重庆市重点实验室(中国)
  • 收稿日期:2025-07-22 出版日期:2025-02-10
  • 通信作者: 蔡磊
  • 基金资助:
    重庆市技术创新与应用发展专项(CSTB2023TIAD-KPX0049); 重庆市科卫联合医学科研重大项目(2024DBXM003)

Advances in immunotherapy strategy for hepatocellular carcinoma and its application in perioperative period

Pengfei Yin1,2, Kun Wu1,2, Huaizhi Wang1,2,3, Lei Cai1,2,3,()   

  1. 1 Institute of Hepatobiliary and Pancreatic Surgery, Chongqing General Hospital, Chongqing University, Chongqing 401147, China
    2 Institute of Hepatobiliary and Pancreatic Surgery, Chongqing General Hospital, Chongqing 401147, China
    3 Key Laboratory of Intelligent Medicine Engineering for Hepatopancreatobiliary Diseases (China), Chongqing 401147, China
  • Received:2025-07-22 Published:2025-02-10
  • Corresponding author: Lei Cai
引用本文:

尹鹏飞, 吴堃, 王槐志, 蔡磊. 肝癌免疫治疗策略及其在围手术期中应用进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 15(01): 21-27.

Pengfei Yin, Kun Wu, Huaizhi Wang, Lei Cai. Advances in immunotherapy strategy for hepatocellular carcinoma and its application in perioperative period[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 15(01): 21-27.

肝细胞癌(肝癌)发病率及病死率高。近年来,随着对免疫微环境研究深入及免疫治疗在晚期肝癌中的广泛应用,以免疫检查点抑制剂为基础的免疫治疗策略逐渐在围手术期开展,其他免疫治疗策略(如过继性细胞治疗、溶瘤病毒等)也取得了明显的进展。围手术期免疫治疗的目的是提升肿瘤可切除性、降低复发转移风险及将部分中晚期不可切除肝癌转化为可切除。然而,具体免疫治疗获益人群、最优免疫治疗方案等问题目前仍亟待解决。本文将从肝癌免疫治疗策略、围手术期免疫治疗研究进展以及免疫治疗疗效预测等方面进行阐述。

Hepatocellular carcinoma (HCC) is a malignancy with high incidence and mortality rates. In recent years, with in-depth study of immune microenvironment and widespread application of immunotherapy in advanced HCC, immunotherapy strategies based on immune checkpoint inhibitors have been gradually employed in perioperative period, and other immunotherapy strategies (such as adoptive cell therapy and oncolytic virus) have also made significant progress. The purpose of perioperative immunotherapy is to improve tumor resectability, reduce the risk of recurrence and metastasis, and make partial unresectable HCC resectable. However, challenges in suitable population of immunotherapy and the optimal immunotherapy regimen remain to be resolved. In this article, the progresses in immunotherapy strategy for HCC, perioperative immunotherapy and prediction of immunotherapy efficacy were illustrated.

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